Based on the results of histological and immunohistochemical observations of a large number of peripheral T cell lymphomas from China, England, Germany and Japan, histological and cytological morphology were correlated with immunophenotype, aetiological association with HTLV-1, and clinical behaviour to produce a working classification of the T cell lymphomas. This classification, based mainly ...

BACKGROUND To determine the correlation of cyclin-dependent kinase inhibitor 1B (p27) expression with clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient prognosis. METHODS Real-time PCR and immunohistochemistry were used to examine the mRNA and protein expressions of p27 in NPC and nasopharyngeal tissues. The relationship of p27 expression levels with clinical fea...

Im • mu • no • his • to • chem • is • try (n.) Microscopic localization of specific antigens in tissues by staining with antibodies labeled with fluorescent or pigmented material. Immunohistochemistry (IHC) is a method used to determine the expression of biomarkers in tissue. This educational guidebook will describe immunohistochemistry as it is used in the pathology laboratory as an aid in the...

Despite the moderate incidence of papillary renal cell carcinoma (PRCC), there is a disproportionately limited understanding of its underlying genetic programs. There is no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphologic classification of PRCC into type 1 and 2 tumors has been recently proposed, but its biological relevance remains...

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histol...

While a history of a single traumatic brain injury (TBI) is associated with the later development of syndromes of cognitive impairment such as Alzheimer’s disease, the long-term pathology evolving after single TBI is poorly understood. However, a progressive tauopathy, chronic traumatic encephalopathy, is described in selected cohorts with a history of repetitive concussive/mild head injury. He...

In this talk we present the update (including the recent SNO results) of our analysis of the neutrino oscillation solutions of the solar and atmospheric neutrino problems in the framework of four-neutrino mixing where a sterile neutrino is added to the three standard ones and the mass spectra present two separated doublets. Such scenarios allow for simultaneous transitions of solar νe, as well ...

red hot pepper is a plant that belongs to the solanaceae family and is known as capsicum annuum. capsaicin is the active ingredient of cayenne pepper. ghrelin is a hormone, which consists of polypeptide structure. ghrelin also contributes to growth hormone secretion, energy balance, food intake and body weight regulator. the aim of this study was the localization and expression of ghrelin in th...

the respiratory tract contains numerous peptides secreted from special pulmonary epithelial cells whichare called endocrine cells. the function of neuroendocrine cells is modulated by amines. serotonin has strong vasomotor and bronchomotor effects in the airway mucosa. the objective of this study was to determine presence and distribution of serotonin-positive endocrine cells in respiratory tra...

granular cell tumors are rare neoplasms of uncertain histogenesis but with a typical histologic appearance composed of cells with characteristic granular cytoplasm. these tumors occur most often in adults as an asymptomatic solitary papule or nodule. multiple granular cell tumors are rare, especially in children and teenagers. we represent a case of multiple granular cell tumors in a 19-year-ol...