Background: CDKN2A, encoding two important tumor suppressor proteins p16 and p14, is a tumor suppressor gene. Mutations in this gene and subsequently the defect in p16 and p14 proteins lead to the downregulation of RB1/p53 and cancer malignancy. To identify the structural and functional effects of mutations, various powerful bioinformatics tools are available. The aim of this study is the ident...

The efficient delivery of nanocarrier-based cancer therapeutics into tumor tissue is problematic. Structural abnormalities, tumor vasculature heterogeneity, and elevated intratumor pressure impose barriers against the preferential accumulation of nanocarrier-based cancer therapeutics within tumor tissues and, consequently, compromise their therapeutic efficacy. Recently, we have reported that m...

objective(s):sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. the present investigation attempted to evaluate the potential of anti-cancer persian gulf sea cucumber species holothuria arenicola (h. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

objective(s)   although photodynamic therapy is considered as a noninvasive method, most photosensitizers are susceptible to  ultrasound.  therefore,  it  is  expected  that  the  combination of  two  activation  methods  might  have  a synergistic effect. this probable effect has been investigated in this study.   materials and methods   this  study  was  conducted  on  colon  carcinoma  tumor...

The durations of the cell cycle intervals of the murine Sarcoma 180 tumor were determined by computer analysis of the fraction-labeled mitosis curve following tritiated thymidine administration. This tumor has a usual total cell cycle duration of 19.6 hr, a DNA synthetic time of 8.3 hr, and a growth fraction of 1. Approximately 38% of cells are in S phase at one time. Hydroxyurea (HU) infusions...

a 28-year-old man with neurofibromatosis type 1(nf1) presented with a tumor in the sciatic nerve and femoral nerve. the differential diagnosis of malignant peripheral nerve sheath tumor was based on clinical, radiological, and histological evidence. the tumor apparently originated in sciatic nerve at the posterior aspect of the left thigh. the lesion was resected totally without neural damage t...

Blache and colleagues (1) state "Although previous studies in mice have observedmodest tumor control with administration of attenuated Salmonella typhimurium (S. typhimurium) alone, it has proven to be less effective in more aggressive tumor models. Moreover, in clinical trials using the S. typhimurium strain VNP20009 for treatment of metastatic melanoma, minimal tumor S. typhimurium colonizati...

Objective(s):Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The present investigation attempted to evaluate the potential of anti-cancer Persian Gulf sea cucumber species Holothuria arenicola (H. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

malignant germ-cell tumors (mgct) are rare tumors of childhood accounting for less than 3% of pediatric malignancies. endodermal sinus tumor (est) forms the most common histologic subtype of mgct. the vagina is an extremely rare site for gcts. an 8-month-old female was admitted with a short history of vaginal bleeding, and a mass protruding from the vagina. she was pale and a mass was palpable ...

purpose: to recognize affective factors in delivering x-ray contrast agents (which have high atomic number) via gallium carrier to liver or lymphatic neoplasm cells.   materials and methods: since uptake of gallium by liver has been reported in numerous researches, it was bonded with a contrast media (metrizoate). x-ray imaging was done to determine geometric features of liver.   results: radio...