bordetella pertussis is a gram negative bacterium that causes respiratory tract infection in human (whooping cough). pertussis toxin (pt) is the main component of current acellular pertussis vaccine and the s1 (subunit1) is the main immunogenic part of it. thus, s1 has been the target of many studies as a potent candidate of acellular vaccine against bordetella pertussis, lacking the side effec...

[S1,Q15=MAC15(S1), P13=MAC13(S1,Q15)] [S2,Q25=MAC25(S2),P23=MAC23(S2,Q25)] [S4,Q46=MAC46(S4),P45=MAC45(S4,Q46)] Q36=MAC36(S1|S2|S3) P35=MAC35(S3, S1|S2, Q15, Q25, Q36) [S3, (S1|S2), Q15, Q25, Q36, P35] Q5B= MAC5B(S1|S2|S3|S4|S5) P56=MAC56(S5, (S1|S2|S3|S4),Q36,Q46,Q5B) [S5, (S1|S2|S3|S4),Q36, Q46, Q5B, P56] P6B=MAC6B(S6, ((S1|S2|S3|S4 |S5)| S7|S8),Q5B,Q7B,Q8B) [S6, ((S1|S2|S3|S4 |S5)| S7|S8),Q5...

We give precise conditions under which the real interpolation space [Y0, X1]θ,p coincides with a closed subspace of [X0, X1]θ,p when Y0 is a closed subspace of codimension one. We then apply this result to nonharmonic Fourier series in Sobolev spaces Hs(−π, π) when 0 < s < 1. The main result: let E be a family of exponentials exp(iλnt) and E forms an unconditional basis in L2(−π, π). Then there...

It is generally believed that prokaryotic translation is initiated by the interaction between the Shine-Dalgarno (SD) sequence in the 5' UTR of an mRNA and the anti-SD sequence in the 3' end of a 16S ribosomal RNA. However, there are two exceptional mechanisms, which do not require the SD sequence for translation initiation: one is mediated by a ribosomal protein S1 (RPS1) and the other used le...

The cellular glucose-regulated protein GRP78-BiP is a member of the HSP70 stress family of gene products, and the protein is a resident component of the endoplasmic reticulum, where it is thought to play a role in the folding and oligomerization of secretory and membrane-bound proteins. GRP78-BiP also binds to malfolded proteins, and this may be one mechanism for preventing their intracellular ...

background and aims: the aim of this study was cloning and expression of rabies virus glycoprotein by a eukaryotic expression plasmid pcdna3.1(+) in bsr cell line. this construct might be used for a potential dna vaccine. materials and methods: glycoprotein gene was synthesized and cloned into pbluescript vector and then sub cloned into eukaryotic expression vector (pcdna3.1(+)). after verifica...