The effects of Ca2+ (0–75 mg/g pectin) and sucrose (0–40%, w/w) or sweeteners (0.1, 0.05% stevia saccharin) pH (3.0, 4.5, 6.8) on the rheological properties gels formed with sunflower pectins purified by conventional method (Conv-pectin), microfiltration (MF-pectin) ultrafiltration (UF-pectin) were investigated. main objective was to develop alternative low-calorie pectin without altered gelati...

Instrumental licking of .4% saccharin solution was increased by the contingent opportunity to lick a less-preferred saccharin solution when the contingency schedule deprived the subject of the contingent response, but not otherwise. Schedules that imposed comparable amounts of response deprivation produced comparable increases in instrumental responding. The results support the hypothesis that ...

The suspected bladder tumor promoters saccharin and cyclamate reversibly inhibited nerve growth factor-induced neurite outgrowth in embryonic chick sensory ganglia, and active concentrations of these artificial sweeteners inhibited binding of 125l-labeled mouse submaxillary gland nerve growth factor as well. The skin tumor promoter phenol also reversibly in hibited neurite outgrowth, while comp...

Saccharin, acting as a weak acid, forms salts with basic APIs and these salts have the desirable property of enhanced water solubility.

Saccharin (o-sulfobenzimide; 1,2-benzothiazole-3(2H)-one 1,1 dioxide; Hsac, Figure 1) is one of the best known and most widely used artificial sweetening agents. Initially, investigation of the interaction of saccharin with different biologically relevant cations attracted great interest due to the suspected carcinogenicity of this compound which, notwithstanding, was recently definitively rule...

The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin co...