Separation Anxiety Disorder (SAD) is the most prevalent anxiety disorder experienced by children, and yet empirical treatment studies of SAD in young children are virtually nonexistent. This paper will describe the development and implementation of an innovative treatment for SAD in young children. First, we will highlight the rationale for developing interventions specifically for SAD in young...

In this issue, Eagles et al et al report that people report that people suffering from seasonal affective disorder suffering from seasonal affective disorder (SAD) are heavy users of primary health (SAD) are heavy users of primary health care services (Eagles care services (Eagles et al et al, 2002, this issue). , 2002, this issue). Nearly 10% of patients attending practices Nearly 10% of patie...

Every winter, especially when the days are short, I feel tired, depressed, and unproductive. Then the spring comes and I start feeling myself again. Is this just a normal seasonal cycle? I've heard about SAD, Seasonal Affective Disorder, but don't know much about it. Answer Dear Melancholy Baby, Somebody must've been feeling a bit clever when they christened the wintertime blues with the acrony...

Bimolecular fluorescence complementation (BiFC) is based on the complementation between two nonfluorescent fragments of the yellow fluorescent protein (YFP) when they are united by interactions between proteins covalently linked to them. We have successfully applied BiFC in Neurospora crassa using two genes involved in meiotic silencing by unpaired DNA (MSUD) and observed macromolecular complex...

BACKGROUND Studies on depression have found that childhood abuse (CA) is associated with a persistent sensitization of the hypothalamic-pituitary-adrenal (HPA)-axis to stress in adulthood. So far, it is unknown whether this HPA-axis sensitization is specific to depression, or whether this is a more general outcome associated with CA in patients with mood and anxiety disorders. The aim of this s...

The present study was undertaken to determine the effects of chronic sinoaortic (baroreceptor) denervation (SAD) on the hemodynamic and sympathetic alterations that occur in the pacing-induced model of congestive heart failure. Two groups of dogs were examined: intact (n = 9) and SAD (n = 9). Both groups of dogs were studied in the control (prepace) state and each week after the initiation of v...

BACKGROUND AND OBJECTIVES Previous studies have found high implicit self-esteem (ISE) to prevail concurrently with low explicit self-esteem (ESE) in socially anxious adults. This suggests that self-esteem discrepancies are associated with social anxiety disorder (SAD). Given that the onset of SAD often occurs in adolescence, we investigated self-esteem discrepancies between ISE and ESE in adole...