Pouched rats can detect Mycobacterium tuberculosis, which causes tuberculosis, in human sputum. Historically, a phosphate-buffered saline solution was added to sputum in the belief that doing so improved rats’ detection of M. tuberculosis, but no relevant data were available. Experiment 1 evaluated rats’ performance on samples with and without phosphate-buffered saline solution added. There was...

High throughput screening (HTS) involves using automated equipment to test a large number of samples against a defined molecular target to identify a reasonable number of active molecules in a timely fashion. Major factors which can influence priorities for the limited resources of the HTS group are projects, productivity, progress and people. The challenge to the HTS group is to provide excell...

In copper-oxides that show high-temperature superconductivity (HTS), the critical temperature (Tc) has a dome-shaped doping dependence. The cause of demise of both Tc and superfluid density ns on the overdoped side is a major puzzle. A recent study of transport and diamagnetism in a large number of overdoped La2-xSrxCuO4 (LSCO) films shows that this cannot be accounted for by disorder within th...

Recently, high-throughput screening (HTS) has become the mainstream technique for drug discovery. Compounds that are synthesized by combinatorial chemistry might be more suitable than natural products to apply to HTS, because the purification procedure is a drawback of using natural products. Nevertheless, natural products remain an extremely important source of drugs. To overcome the demerits ...

The use of hydrophilic gel contact lenses as a carrier of a non-isotonic saline solution provokes an irreversible increase in corneal thickness in the in-vivo rabbit eye. Studies on humans confirm the nature of the animal response, and it is therefore suggested that particular care should be taken when patients prepare saline solutions.

www.nursingcenter.com SUPPOSE YOU’RE caring for a patient who’s receiving 5% dextrose in 0.9% sodium chloride solution at 100 ml per hour, along with 600 mg of clindamycin every 8 hours and 80 mg of tobramycin every 8 hours. Piggybacking the antibiotics into the primary administration set is a common practice, but using a secondary set for each medication requires frequent connection and discon...

Haemorrhagic shock, a leading cause of mortality, frequently accompanies cardiac interventions. The administration of small volumes of hypertonic saline solutions and crystalloid solutions may reduce the severity and duration of shock, and result in a decrease in adverse outcomes. Under general anaesthesia, hypotension was induced in 12 healthy dogs. After 30 min, dogs received either hypertoni...

Adequate water intake, supporting both cardiovascular function and evaporative cooling, is a critical factor in mitigating the effects of heat waves, which are expected to increase with global warming. However, the regulation of water intake during periods of intermittent heat exposure is not well understood. In this study, the effects of access to water or no access during intermittent heat ex...

PURPOSE Sepsis severity and mortality risk require aggressive therapy which includes hemodynamic support. The best fluid for volume replacement, however, is controversial. This study aimed to compare 0.9% isotonic saline solution versus 7.5% hypertonic saline solution as volume replacement fluid in sepsis induced by cecum ligation plus puncture rats. METHODS This experimental trial included 3...

Lipid biosynthesis in the adult testis in several species has been reported (Davis, Bridges & Coniglio, 1966; Bridges & Coniglio, 1970; Carpenter, 1971; Ayala, Gaspar, Brenner, Peluffo & Kunau, 1973). Similar studies in the fetal testis are not available. The purpose of this study was to investigate the ability of the testis of the human fetus during the first trimester to synthesize fatty acid...