The majority of phase III clinical trials use a 2-arm randomized controlled trial with 50% allocation between the control treatment and experimental treatment. sample size calculated for these normally guarantee power at least 80% certain Type I error, usually 5%. However, calculations, do not typically take into account total patient population that may benefit from investigated. In this artic...

Regression analysis is the method of choice for the production of covariate-dependent reference limits. There are currently no recommendations on what sample size should be used when regression-based reference limits and confidence intervals are calculated. In this study we used Monte Carlo simulation to study a reference sample group of 374 age-dependent hemoglobin values. From this sample, 50...

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Sample size determination is a prerequisite for statistical surveys. A comprehensive overview of the Bayesian approach for computation of the sample size, and a comparison with classical approaches, is presented. Two surveys are taken as example to illustrate the accuracy and efficiency of each approach, and to make recommendations about which method is preferred. The Bayesian approach of sampl...