The Ewing sarcoma family of tumors (ESFT) comprises morphologically heterogeneous tumors that are characterized by nonrandom chromosomal translocations involving the EWS gene and one of several members of the ETS family of transcription factors. The translocation t(11;22)(q24;q12) is the most common and leads to the formation of the EWS-FLI1 fusion protein, which contributes to ESFT pathogenesi...

The primitive neuroectodermal tumor (PNET) belongs to a group of highly malignant tumors and is composed of small round cells of a neuroectodermal origin. Categorized in the same tumor family as Ewing sarcoma, the PNET is most likely to occur in bones and soft tissues. However, a small number of PNET cases arising in the pelvis have been reported as well. We present three cases of pelvic PNET: ...

We have examined a wide range of cultured human tumor cell lines and found that a specific subset of tumors expresses the cholecystokinin (CCK) gene. All neuroepitheliomas (eight) and Ewing sarcoma (eight) cell lines that were tested express CCK RNA. In addition, two of six rhabdomyosarcoma cell lines also express the CCK gene, suggesting that rhabdomyosarcomas are probably heterogenous and tha...

Malignant phyllodes tumors are relatively rare, accounting for 0.3 to 0.9% of all tumors of the breast. This tumor metastasizes approximately 20% of the cases depending upon the histologic behavior (1). The most common site of metastasis is the lung (1). Of all possible organs, metastasis to the skeletal muscle is relatively unusual. Moreover, imaging findings of metastasis to the skeletal musc...

Objective: The present study was done to find out the frequency of malignant tumors of bone and to categorize the prevelence of various histological types of osseous malignancies with respect to age, sex and site of origin. Setting: This study included consecutive cases of malignant bone tumors, which were diagnosed in the department of pathology at the Aga Khan University Hospital, Karachi dur...

Sarcoma 180 grew for only 10-14 days when implanted in bilaterally adrenalectomized male Swiss mice. The tumors completely regressed within 30 days. Untreated adrenalectomized mice never had tumors larger than 15 mm. in diameter. Adrenalectomy of mice after the tumor was established also resulted in regression of Sarcoma 180. Daily injections of Cortisol acetate or corticosterone at dosages fro...

Introduction: Soft tissue tumors (STTs) are a diverse group of neoplasms. It varies from the most common benign to some self-limited lesions and rare malignant soft tumors. Because overlap in their clinical radiological characteristics, histopathology is crucial determining diagnosis.
 Objectives: To study relative frequencies types (benign, intermediate malignant) as well histological pat...

Extraosseous Ewing’s sarcoma/primitive neuroectodermal tumor is a rare malignant tumor with poor outcome. It is mostly reported in the second decade of life with equal in males and females. It is an aggressive tumor with unavoidable multiple recurrences and relatively poor prognosis. These tumors can be easily misdiagnosed for different tumors due to lack of established diagnostic pathological ...

The Ewing sarcoma family of tumors (ESFT) encompasses a group of highly aggressive, morphologically similar, malignant neoplasms sharing a common spontaneous genetic translocation that affect mostly children and young adults. These predominantly characteristic, small round-cell tumors include Ewing's sarcoma of the bone and soft tissue, as well as primitive neuroectodermal tumors (PNETs) involv...