BACKGROUND Sciatic nerve block is widely used for anesthesia and analgesia in lower limb surgery, traditional method used for sciatic nerve block is nerve stimulation guidance. Whether the use of ultrasound-guided technology can increases the success rate of sciatic nerve block and provide other benefits are not defined. This meta-analysis was aimed to clarify this issue. METHOD We searched P...

Intracellular recording and extracellular field potential (FP) recordings were obtained from spinal cord dorsal horn neurons (laminae I-IV) in a rat transverse slice preparation with attached dorsal roots. To study changes in synaptic inputs after neuroma formation, the sciatic nerve was sectioned and ligated 3 weeks before in vitro electrophysiological analysis. Horseradish peroxidase labeling...

AIM To analyze the therapeutic effects of long-term alpha lipoic acid (A-LA) and vitamin B12 use via histomorphometric methods and electron microscopy in the transected sciatic nerves of rats. MATERIAL AND METHODS Forty rats were randomized into five groups (n=8/group). In group I, 1 cm segment of sciatic nerve was resected without any other intervention. In group II (sham), following right s...

The complex interactions among the structural features of axon, its myelin sheath and its length, determine the nature of nerve impulse conduction.. In addition, fibers of different diameters and degree of myelination determine the nerve conduction velocity (NCV). It is therefore, hypothesized that for the same nerve, the NCV may differ in animals, due to the differences in the leg architecture...

Glial cell line-derived neurotrophic factor (GDNF) has potent trophic effects on adult sensory neurons after nerve injury and is one of a family of proteins that includes neurturin, persephin, and artemin. Sensitivity to these factors is conferred by a receptor complex consisting of a ligand binding domain (GFRalpha1-GFRalpha4) and a signal transducing domain RET. We have investigated the norma...

BACKGROUND AND OBJECTIVES Recently, administration of sciatic nerve block has been revised due to the potential benefit for postoperative analgesia and patient satisfaction after the advent of ultrasound. The aim of this study was to describe the anatomical relations of the sciatic nerve in the popliteal fossa to determine the optimal distance the needle must be positioned in order to realize t...

BACKGROUND The aim of this study was to investigate the effects of negative pressure therapy in the regeneration of the rabbit sciatic nerve using vacuum assisted closure (VAC). MATERIAL AND METHODS Thirty male New Zealand white rabbits underwent surgical injury of the sciatic nerve, followed by negative pressure therapy using vacuum assisted closure (VAC), in three treatment groups: Group A: 0...

The rat sciatic nerve is a well-established model for the study of recovery from peripheral nerve injuries. Traditional methods of assessing nerve regeneration after nerve injury and repair, such as electrophysiology and histomorphometry, despite widely used in neural regeneration experiments, do not necessarily correlate with return of motor and sensory functions. The aim of this experimental ...

Sciatic is Greek word derived from “Ischiadicus”. The sciatic nerve is also known as the ischiadic nerve or ischiatic nerve, is a large nerve in humans and other animals. It is the longest and widest single nerve in the human body. The sciatic nerve is comprised of five nerves. It is formed on the right and left hand side of the lower spine. It is derived from the spinal nerves L4-S3. It contai...

Muscle tone abnormalities are associated with many CNS pathologies and severely limit recovery of motor control. Muscle tone depends on the level of excitability of spinal motoneurons and interneurons. The present study investigated the following hypotheses: (1) direct current flowing from spinal cord to sciatic nerve [spinal-to-sciatic direct current stimulation (DCS)] would inhibit spinal mot...