The process of aligning a group of protein sequences to obtain a meaningful Multiple Sequence Alignment (MSA) is a basic tool in current bioinformatic research. The development of new MSA algorithms raises the need for an efficient way to evaluate the quality of an alignment, in order to select the best alignment among the ones produced by the available algorithms. A natural way to evaluate the...

Abstract The superposition of small molecules is a standard technique in molecular modeling and for some more advanced silico applications drug discovery critical prerequisite. aims superposing are manifold. An assessment the 3D similarity, an understanding SAR compound series, or ultimately estimate likelihood to be active selective against target protein interest. Considering so many objectiv...

Introduction: Accurate evaluation of metastasis and life prognosis is essential for selecting a suitable therapeutic strategy for metastatic spine tumors owing to limitations in treatment options. For this purpose, various classification, evaluation, and scoring systems have been developed. Methods: Classification, evaluation, and scoring systems for metastatic spine tumors reported to date wer...

Background. This paper presents the study concerning hot-spot selection in the assessment of whole slide images of tissue sections collected from meningioma patients. The samples were immunohistochemically stained to determine the Ki-67/MIB-1 proliferation index used for prognosis and treatment planning. Objective. The observer performance was examined by comparing results of the proposed metho...

Accurate scoring of protein-ligand interactions in molecular docking and virtual screening is still challenging. Despite great efforts, the performance of existing scoring functions strongly depends on the target structure under investigation. Recent developments in the direction of target-class-specific scoring methods and machine-learningbased classification models reveals a significant impro...

MOTIVATION In order to design effective HIV inhibitors, studying and understanding the mechanism of HIV protease cleavage specification is critical. Various methods have been developed to explore the specificity of HIV protease cleavage activity. However, success in both extracting discriminant rules and maintaining high prediction accuracy is still challenging. The earlier study had employed g...