Scorpions and their venoms have been employed in medication since thousands of years in Asia. The scorpion venom is an extremely advanced mixture of salts, nucleotides, biogenic amines, enzymes, mucoproteins, peptides and proteins (e.g. Neurotoxins). Scorpion venoms contain peptides that block or modify ion-channel function and present some doable applications to regulate cell excitability. Spe...

Introduction: Many molecules can be labeled by iodine. Some of labeled substances are used for investigations of cancer treatment, biodistribution study in body, receptor binding, secrete pathway etc. Peptides are biomolecules and can be labeled by 131Iodine. ICD- 85 is a tri-peptide derived from Iranian brown snake venom and scorpion venom. This tri-peptide treats cancer by i...

Many strategies have been developed to improve vaccine delivery in the past decade. The aim of the current study was to develop a nanoparticulate system based on ionic gelation between chitosan and tripolyphosphate in order to load Androctonus Crassicauda scorpion venom. The best formulation was selected according to the highest association efficiency, loading capacity, optimum particle size an...

BACKGROUND Scorpion sting is a major health problem in Iran. The aim of current study was to measure the incidence rates of scorpion stings, mortality, recovery, and affected age groups. The results of treatment with and without anti venom also were considered in the entire country during 2009. METHODS All the data were collected from emergency section of different hospitals and then were ana...

For over 30 years, HIV/AIDS has wreaked havoc in the world. In the absence of an effective vaccine for HIV, development of new anti-HIV agents is urgently needed. We previously identified the antiviral activities of the scorpion-venom-peptide-derived mucroporin-M1 for three RNA viruses (measles viruses, SARS-CoV, and H5N1). In this investigation, a panel of scorpion venom peptides and their der...

Indian red scorpion (Mesobuthus tamulus; MBT) produces lethal stings and is a matter of concern in certain parts of India. MBT envenomation produces multi-systemic involvement, thus presents difficulty in the management. Symptomatic treatment has been practiced earlier that failed to relieve the toxic effects of the venom. Therefore, present manuscript deals with pathophysiologically based appr...

Objective: Mesobuthus tumulus is the most lethal among all poisonous species of scorpion. Aristolochia indica is one of the plants which have long been used in traditional herbal medicine for the treatment of poisoning by animal bites. Hence the study was planned to evaluate the ethanolic extract of Aristolochia indica for the treatment of Mesobuthus tamulus envenoming. Materials and Methods: C...

conclusions hemiscorpius lepturus venom in sheep can cause severe changes in some of the coagulation factors. this should be considered as part of the pathogenesis of scorpion sting and seriously in the treatment protocol of scorpion sting victims. results in the studied groups, the effect of time on pt and platelets counts was significant (p < 0.05); however, it did not have a significant effe...

background: scorpion sting envenomation generally causes treatable local and systemic effects; however, in rare cases, the victims might experience sequels in end organs such as central nervous system. in the present paper, a case of relatively self-limiting demyelinating polyneuropathy following a butidae sting is presented and the possible mechanisms are discussed.  case presentation: a 19-ye...