It was demonstrated that gamma-irradiated L-929 cells support plaque formation by three strains of Rickettsia tsutsugamushi and representative species of the spotted fever and typhus group rickettsiae. Sensitivity of the plaque assay for detection of viable scrub typhus rickettsiae was similar to that achieved with intraperitoneal inoculation of random-bred mice. The concentration of irradiated...

Scrub typhus is a mite borne infection, caused by Orientia tsutsugamushi. It is a common cause of pyrexia of unknown origin, especially in the Indian subcontinent. Although it is well known that the infection can affect various systems, and present itself in myriad ways, we present a rare finding of opsoclonus associated with scrub typhus infection. It emphasizes on how even common and well kno...

Scrub typhus, an infectious disease caused by a bacterium transmitted “chigger” mites, constitutes public health problem in Thailand. Predicting epidemic peaks would allow implementing preventive measures locally. This study analyses the predictability of time series incidence scrub typhus aggregated at provincial level. After stationarizing series, evaluation Hurst exponents indicates province...

To investigate the risk factors of scrub typhus infection in Beijing, China, a case-control study was carried out. Cases (n = 56) were defined as persons who were diagnosed by PCR and serological method within three years. Three neighborhood control subjects were selected by matching for age and occupation. Living at the edge of the village, living in the houses near grassland, vegetable field ...

Scrub typhus is a rickettsial disease, caused by Orientia tsutsugamushi, which is transmitted via the bite of a chigger. This disease is one of the most important infectious diseases in the Asia-Pacific area; however, a severe infant case has not yet been reported. Here, we present the case of an 8-month-old boy with scrub typhus accompanied by hemophagocytic lymphohistiocytosis (HLH). His rapi...

Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene ...

Scrub typhus (tsutsugamushi disease) is caused by orienta tsutsugamushi and transmitted by trombiculid mite. Approximately 1 million infections occur each year globally and it occurs mostly in Asia. It can affect all age groups however very rare case has been reported among neonates. Here we report a newborn with scrub typhus disease. Whenever a newborn present with clinical symptoms of the dis...

We describe a 64-year-old man with scrub typhus who presented with both polyneuropathy and cerebral infarction. A eurological examination revealed a confused mental state, stiff neck, hearing impairment, symmetric weakness, sensory loss, and ataxia. Electrophysiologic studies showed demyelinating sensorimotor polyneuropathy and sensorineural hearing loss. Brain magnetic resonance imaging showed...

BACKGROUND Scrub typhus is a documented disease in Himachal Pradesh, but there have been no clinico-epidemiological studies in this area. The present study is done with IgM ELISA as a diagnostic test which has higher sensitivity and specificity as most of previous studies had used Weil Felix test as a diagnostic test. METHODOLOGY This was a prospective observational study. All the patients mo...

We report a case of acute calculous cholecystitis through scrub typhus. A 69-year-old woman presented with a history of general myalgia, fever, and right abdominal pain. She referred to our hospital for surgical treatment of clinically suspected acute cholecystitis. Physicians concluded the cause of cholecystitis as gall bladder (GB) stone and proper antibiotics treatment of scrub typhus was st...