background: the strong link between sealer solubility and periapical reinfection indicates that water solubility of new sealers should be studied. this study aimed to assess the water solubility of five root canal sealers (ah-26, topseal, 2-seal, acroseal, and roeko seal automix [rsa]). materials and methods: in this in vitro experimental study, 30 specimens were fabricated from each of the abo...