Many peripheral reproductive tissues have been found to contain gonadotrophin-releasing hormone (GnRH) and express the GnRH gene at low levels, presumably because the hormone functions in a paracrine/autocrine fashion. This study was designed to investigate and characterize GnRH gene expression in human endometrial tissue at different stages of the endometrial cycle. Reverse transcriptase-polym...

The strong association between endometriosis and infertility is of high clinical significance. High proliferative bias in eutopic endometrium during the secretory phase a hallmark endometriosis, which may result occurrence implantation failure resultant endometriosis. ErbB family proteins regulates proliferation capacity endometrium, potentially causing endometrial hostility to process However,...

conclusions the current study indicated that the immunoreactivity of secretory iga might have no direct correlation with the colonization of indigenous flora and rejection of exogenous strains in adults. the relationship of microbes, host and dental caries should be in the light of coevolved microecosystem as a whole, but not caused by one factor alone. results the results showed that naturally...

BACKGROUND Diagnosis of premalignant endometrial lesions is a major challenge to pathologists. The D-score system is more reproducible than the WHO scheme, however it is not widely available, this study attest a simple custom-made workstation for estimation of the "D-score". MATERIAL AND METHODS Fifteen endometriam with low grade hyperplasia, fifteen proliferative and eight secretory phase en...

Introduction The expression of genes in female reproductive organs is influenced by the cyclic changes hormone levels during menstrual cycle. While molecular endometrium that facilitate embryo implantation have been extensively studied, there limited knowledge about impact cycle on cervical cells. Cervical cells can be easily and routinely collected using a cytobrush gynecological examination, ...

Endometriosis, defined as the presence of endometrial cells outside of the uterine cavity, is a major cause of infertility and pelvic pain, afflicting more than 10% of reproductive age women. Endometriosis is a chronic inflammatory disease and lipopolysaccharide promotes the proliferation and invasion of endometriotic stromal cells. Cysteine-rich secretory protein LCCL domain-containing 2 (CRIS...

We have studied concurrent apical/basolateral and regulated/constitutive secretory targeting in filter-grown thyroid epithelial monolayers in vitro, by following the exocytotic routes of two newly synthesized endogenous secretory proteins, thyroglobulin (Tg) and p500. Tg is a regulated secretory protein as indicated by its acute secretory response to secretagogues. Without stimulation, pulse-la...

To examine the sex steroid-dependent growth mechanisms of the human endometrium, the expression of steroid receptor coactivators [steroid receptor coactivator-1 (SRC-1) and p300/CREB-binding protein (p300/CBP)] and corepressors (nuclear receptor corepressor and silencing mediator for retinoid and thyroid hormone receptors) was examined by immunohistochemistry, using 50 samples of normal endomet...