The Na+/H+ exchangers (NHE) are a family of proteins that regulate intracellular pH, sodium levels and cell volume, contribute to the control cycle, proliferation, migration vesicle trafficking. However, despite their physiological importance, detailed molecular-level structural information for NHE has been lacking. Although number prokaryotic structures sodium/proton antiporters known, it is n...

This study characterizes different MTP1 (metal tolerance protein)/ZAT (zinc transporter) homologs involved in zinc (Zn) homeostasis plants. BLAST analysis of AtMTP1 protein against 15 plant species showed 21 homologs. These generally contain ~400 residues, six transmembrane helices and cation transporter activity (GO:0008324), which can be utilized predicting Zn uptake mechanisms. genes having ...

Introduction: Paraoxon (the neurotoxic metabolite of organophosphorus (OP) insecticide, parathion) exerts acute toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and hence overstimulation of the cholinergic system. Since, reports on changes in the level of γ- amino butyric acid (GABA) during OP-induced convulsion have bee...

This study examines the concept of personal brand equity (PBE) and relationship between constructs (pb) Personal Branding (PB). article provides insight into PBE. The definition three main corresponding key variables are reviewed based on existing literature. defines construct Brand Equity as value added to an individual’s reputation by their branding efforts. systematic literature review is ke...

background :5httlpr polymorphism (5- hydroxytryptamine transporter linked promoter region polymorphism) is the most widely studied genetic variant in psychiatry. the present study is a modest effort at ascertaining the role of 5ht transporter linked promoter region polymorphism (5httlpr) in anxiety and depressive disorders in kashmir (india).the aim of this study was to examine 5-hydroxy trypta...

conclusions the results of the study show no significant association between norepinephrine transporter polymorphism scl6a2 and adhd. results the percentages of adhd subtypes for combined, inattentive, and hyperactive/impulsive were 72.2%, 17.2%, and 11.9%, respectively. there was no significant association between norepinephrine transporter polymorphism and adhd (p = 0.81). moreover, no signif...

Controlling the activation of platelets is a key strategy to mitigate cardiovascular disease. Previous studies have suggested that the ATP-binding cassette (ABC) transporter, ABCC4 functions in platelet dense granules. Using plasma membrane biotinylation and super resolution microscopy, we demonstrate that ABCC4 is primarily expressed on the plasma membrane of both mouse and human platelets. Pl...

introduction: prolonged and intermittent oxygen pre-exposure is associated with protection against ischemic reperfusion (ir) injury. in the current study, attempts were made to investigate the relationship between exposure to prolonged and intermittent normobaric hyperoxia (nbho) and expression of excitatory amino acids transporters (eaats) and tnf-α level. method: rats were divided into four m...