introduction: screening of newborns with seizure, who have curable pathologic brain findings, might be able to improve their final outcome by accelerating treatment intervention. the present study aimed to evaluate the brain ultrasonography findings of newborns hospitalized with complaint of seizure. methods: the present cross-sectional study designed to evaluate brain ultrasonography findings ...

objective 1-3% of the population suffer from epilepsy. up to 30% of them develop refractory epilepsy and their seizures occur more than once per month despite receiving at least 2 first line antiepileptic drugs. in  this group, more efficacious antiepileptics are needed. this study was undertaken to evaluate the efficacy and safety of oxcarbazepine as an adjunction therapy in children with refr...

In 7 children with unusually severe or frequent reflex anoxic seizures atropine treatment, which was well tolerated, reduced seizure frequency by a mean value of 98%. Treatment withdrawal (five patients) was followed by an increase in seizure frequency and reintroduction (three patients) by restoration of control.

OBJECTIVE To investigate whether mammalian target of rapamycin complex 1 (mTORC1) inhibitors could reduce seizure frequency in children with tuberous sclerosis complex (TSC). METHODS Due to slow inclusion rate, target inclusion of 30 children was not reached. Twenty-three children with TSC and intractable epilepsy (age 1.8-10.9 years) were randomly assigned (1:1) to open-label, add-on sirolim...

AIMS In temporal lobe epilepsy (TLE) due to hippocampal sclerosis reorganisation in the memory encoding network has been consistently described. Distinct areas of reorganisation have been shown to be efficient when associated with successful subsequent memory formation or inefficient when not associated with successful subsequent memory. We investigated the effect of clinical parameters that mo...

Dietary habits have been rarely associated with seizure frequency in patients with epilepsy. We report a case of a man with a partial symptomatic epilepsy whose daily habit of heavy coffee drinking was associated with an increased seizure frequency. This patient witnessed a dramatic decrease in the frequency of his seizures after stopping coffee ingestion. Caffeine is a global stimulant and the...

We describe a treatment alternative for intractable, startle-provoked, epileptic seizures in four children aged between 8 and 14. Three of the four children had symptomatic localization-related epilepsy. They all suffered from intractable epilepsy precipitated by sudden sounds. The fact that seizures tended to occur with high frequency - more than one seizure a day - had a clear impact on daily...

PURPOSE This study was conducted to evaluate the efficacy and safety of anterior corpus callosotomy with a keyhole approach on refractory seizures and to evaluate this procedure for drop attacks (DAs) and generalized tonic-clonic seizures (GTCSs). METHODS All refractory seizure patients underwent anterior corpus callosotomy (n=31) without other epilepsy surgery. Seizure response and procedure...

Some reports have suggested that epileptic seizures might occur more frequently at times of enhanced disturbance of the geomagnetic field. This study examines this putative association using 4101 seizures from 22 epileptic patients where the seizure times were known to within a day or better. A measure of the geomagnet-ic fluctuation level for the seizure day, and the days preceding the seizure...

This study was to examine the therapeutic effect of low-frequency electric stimulation (LFS) on the epileptogenic focus in amygdale-kindled rats, and to find out the optimal stimulus parameters. A microelectrode was implanted into the right amygdale of adult male rats. After fully kindling, LFS was delivered to the right amygdale (through the electrode) between seizures to induce stimulus train...