OBJECTIVE To delineate the temporal patterns of outcome and to determine the probability of seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy. METHODS Patients in whom epilepsy was diagnosed and the first antiepileptic drug prescribed between July 1, 1982, and April 1, 2006, were followed up until March 31, 2008. Outcomes were categorized into 4 patterns:...

Purpose: The aim of this study was to assess the probability of bacterial meningitis presenting with a first simple febrile seizure or complex febrile seizure without any conspicuous signs of meningitis. Methods: This was a record based cross-sectional study of 564 patients of 6-24 months of age and was evaluated in a paediatric emergency department between 2007 and 2013 for their first febrile...

objective simple febrile seizures are the most common form of childhood seizures,often recurring within the first twenty-four hours. this study was conducted to determine the probable role of low serum  sodium levels in predicting seizure recurrence in febrile children. materials & methods for the study, 226 patients with seizures, aged between 6 months to 5 years, were divided into 3 groups of...

The identification of variables predictive of good seizure control following surgical tumor resection in adult glioma patients with tumor-related epilepsy would greatly benefit treatment decisions. Therefore, we analyzed the clinical data of adult patients with tumor-related epilepsy who underwent tumor resection at our institute between November 2011 and August 2013. Patients were divided into...

PURPOSE The study aim was to evaluate pharmacotherapy effects and long-term seizure outcomes in patients with juvenile absence epilepsy (JAE) during a five-year follow-up period. The secondary aim was to identify factors from patient history and determine their influence on seizure control. METHOD We retrospectively studied 46 patients with JAE in the period between 2006 and 2011. The age at ...

OBJECTIVE To examine the seizure trajectories of adults with epilepsy developing drug-resistant epilepsy (DRE) and to identify the predictors of seizure trajectory outcome. METHODS Adult patients failing two antiepileptic drugs (AEDs) due to inefficacy and starting their third AED at a tertiary epilepsy center were followed for seizure trajectory outcome during medical management. Seizure tra...

OBJECTIVE Almost two-thirds of patients with Sturge-Weber syndrome (SWS) have epilepsy, and half of them require surgery for it. However, it is well known that scalp electroencephalography (EEG) does not demonstrate unequivocal epileptic discharges in patients with SWS. Therefore, we analyzed interictal and ictal discharges from intracranial subdural EEG recordings in patients treated surgicall...

OBJECTIVE Early and accurate diagnosis of patients with psychogenic nonepileptic seizures (PNES) leads to appropriate treatment and improves long-term seizure prognosis. However, this is complicated by the need to record seizures to make a definitive diagnosis. Suspicion for PNES can be raised through knowledge that patients with PNES have increased somatic sensitivity and report more positive ...

PURPOSE To establish the long-term efficacy and tolerability of vagus nerve stimulation (VNS) in children with a Lennox-like syndrome. METHOD This study was a longitudinal observational prospective cohort analysis. Baseline: 6 months. FOLLOW-UP 24 months. Screening (baseline and every 6 months): MRI (baseline only), EEG, neuropsychological evaluation, ECG and blood sampling for antiepilepti...

how to cite this article: taghdiri mm, bakhshandeh bali mk, karimzadeh p, ashrafi mr, tonekaboni sh, ghofrani m. comparative efficacy of zonisamide and pregabalin as an adjunctive therapy in children with refractory epilepsy. iran j child neurol. 2015 winter;9(1):49-55. abstract objective approximately one third of epileptic children are resistant to anticonvulsant drugs. this study evaluates t...