Nanostructure of self-assembled particles, such as micelles and polymersomes play an important role in drug delivery, especially in tumor therapy. Particles with various structures are regarded as perfect candidates for controlled drug delivery due to highly selective cellular uptake and exceptional payload that increases drug delivery efficiency [1-4]. Size, as another benefit that can be cont...

Two-dimensional (2D) materials of atomic thickness have emerged as nano-building blocks to develop high-performance separation membranes that feature unique nanopores and/or nanochannels. These 2D-material membranes exhibit extraordinary permeation properties, opening a new avenue to ultra-fast and highly selective membranes for water and gas separation. Summarized in this Minireview are the la...

Stimulated Raman scattering microscopy was used to assess the permeation of topically applied drugs and formulation excipients into porcine skin. This chemically selective technique generates high-resolution 3D images, from which semi-quantitative information may be elucidated. Ibuprofen, applied as a close-to-saturated solution in propylene glycol, was directly observed to crystallise in/on th...

In order to promote the selective water permeation through porous filler, hydrophilic MOF-801 crystals with superior water adsorption ability were incorporated into chitosan (CS) matrix to fabricate MOF-801/CS mixed matrix membranes (MMMs) for pervaporation dehydration of ethanol. Both the experimental and molecular simulation results confirm the selective adsorption of water molecules in MOF-8...

OBJECTIVES The purpose of this study was to investigate the permeation of the low-volatile solvent limonene through different disposable, unlined, unsupported, nitrile exam whole gloves (blue, purple, sterling, and lavender, from Kimberly-Clark). METHODS This study utilized a moving and static dextrous robot hand as part of a novel dynamic permeation system that allowed sampling at specific t...

Water is a major component of the cell, forming between 70 and 95% of its mass. It can cross lipid bilayers of all biological membranes by simple diffusion. However, diffusion is a slow, non-regulated process which cannot account for selective transmembrane water permeation as occurs in many fluid transporting tissues during normal physiological processes. This suggested the existence of additi...

Title of dissertation: MITOCHONDRIAL VDAC AND BACTERIAL PORA/C1: ION PERMEATION AND SELECTIVITY Alexander G. Komarov, Doctor of Philosophy, 2005 Dissertation directed by: Professor Marco Colombini Department of Biology VDAC and PorA/C1 are large diameter channels with properties reminiscent of those found in narrow channels. VDAC, located in the mitochondrial outer membrane, shows high selectiv...

Membrane channel proteins of the aquaporin family are highly selective for permeation of specific small molecules, with absolute exclusion of ions and charged solutes and without dissipation of the electrochemical potential across the cell membrane. We report the crystal structure of the Escherichia coli glycerol facilitator (GlpF) with its primary permeant substrate glycerol at 2.2 angstrom re...

OBJECTIVES Microvascular invasion and microlymphatic permeation are indicators of microscopic tumour invasion into small vessels and have been considered to be powerful prognostic indicators for non-small-cell lung cancer (NSCLC). Several studies have suggested that these should be included in the TNM classification, but, there have been conflicting results regarding the prognostic impact of mi...