Ammonium chloride promotes the selective formation of monosubstituted ureas under microwave irradiation. Most nucleophiles, acid-labile functionalities, and protecting groups are well tolerated in this reaction. By avoiding transition metals mineral acids, methodology offers a more sustainable alternative for synthesis their analogs.

Adenosme mhlblts rat vascular smooth muscle cell (SMC) growth However, the effects of adenosme on human vascular SMC prohferahon and synthesis of extracellular matnx protems, such as collagen, are unknown The objective of this study was to characterize the effects of exogenous and endogenous (SMC-denved) adenosme on human aotic SMC prohferatlon and collagen synthesis Growth-arrested SMCs were s...

Aceylation of cyclooxygenase (COX)-2 by aspirin can trigger the formation of 15(R)-epilipoxin A4, or aspirin-triggered lipoxin (ATL). ATL exerts protective effects in the stomach. Selective COX-2 inhibitors block ATL synthesis and exacerbate aspirin-induced gastric damage. Nitric oxide-releasing aspirins, including NCX-4016, have antiplatelet effects similar to aspirin but do not cause gastric ...

Adenosine inhibits rat vascular smooth muscle cell (SMC) growth. However, the effects of adenosine on human vascular SMC proliferation and synthesis of extracellular matrix proteins, such as collagen, are unknown. The objective of this study was to characterize the effects of exogenous and endogenous (SMC-derived) adenosine on human aortic SMC proliferation and collagen synthesis. Growth-arrest...

Selective oxidation of organic compounds is incredibly important in the production broad range chemicals. As such, these reactions attract a great deal research attention, particularly where conventionally synthesis uses harsh and corrosive reaction conditions. To decrease energy consumption, improve yields mitigate environmental impacts, heterogeneous photocatalysis has emerged as green facile...

Phase transformation from layered double hydroxides (LDHs) into mixed metal oxides (MMOs) has been widely used in various catalytic applications owing to its numerous advantages over conventional synthesis methods. Herein we report the results of selective phase LDHs spinels and delafossites for preparation phase-pure MMO catalysts. Pure cuprous cupric were selectively obtained through heat tre...

to obtain drugs which are more selective at benzodiazepine (bzd) receptors, design and synthesis of functionally selective ligands for bzd receptors is the current strategy of our pharmaceutical chemistry department. the affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

Omeprazole, (6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole is a well-established prescribed drug, exhibits proton pump inhibitor activity. In this work, a novel, facile, economical and selective oxidation approach using H3PW12O40 as Keggin type heteropolyacids along with H2O2 in the ...

A convergent, highly stereoselective total synthesis of (-)-spinosyn A (1) is described. Key features of the synthesis include the transannular Diels-Alder reaction of macrocyclic pentaene 11 and the transannular Morita-Baylis-Hillman cyclization of 12 that generates tetracycle 26. The total synthesis of (-)-spinosyn A was completed by a sequence involving the highly beta-selective glycosidatio...

Adenosme mhlblts rat vascular smooth muscle cell (SMC) growth However, the effects of adenosme on human vascular SMC prohferahon and synthesis of extracellular matnx protems, such as collagen, are unknown The objective of this study was to characterize the effects of exogenous and endogenous (SMC-denved) adenosme on human aotic SMC prohferatlon and collagen synthesis Growth-arrested SMCs were s...