We examined the promoter selectivity of RNA polymerase (RNAP) from Streptomyces coelicolor at two growth phases by in vitro transcription. Distinct sets of promoters were preferentially recognized by either exponential or stationary phase RNAP. No change in molecular weight or net charge of the core subunits was observed, suggesting that the associated specificity factors determined phase-speci...

the bottom trawl selectivity parameters (22mm cod-end mesh size) were determined for saurida undosquamis , mullus barbatus , upeneus pori , and pagellus erythrinus along karatas coasts of turkey in northeastern mediterranean waters during fishing season for the year 2002-2003. the lengths at first capture (l 50 ) values for s. undosquamis , m. barbatus , u. pori and p. erythrinus were 12.57, 9....

Factor IXa (FIXa), a blood coagulation factor, is specifically inhibited at the initiation stage of the coagulation cascade, promising an excellent approach for developing selective and safe anticoagulants. Eighty-four amidinobenzothiophene antithrombotic derivatives targeting FIXa were selected to establish three-dimensional quantitative structure-activity relationship (3D-QSAR) and three-dime...

This paper describes the design and implementation of a second-order switched-capacitor (SC) bandpass (BP) filter with very wide quality factor (Q) programmability range. The filter selectivity is digitally programmed by varying the effective sampling frequency of an SC branch, without modifying any capacitor value. The proposed approach allows a quasi-continuous Q-factor tunability avoiding, i...

Quantum chemical calculations are used to explore the origins of regioselectivity for proton-, Pt(II)- and Pd(II)-promoted cyclizations of 1,5-hexadienes, 5-aminoalkenes, and allylic acetimidates. The strain associated with achieving carbonium ion-like transition state geometries is shown to be a key factor in controlling 5-exo vs. 6-endo selectivity.

We demonstrate a novel method for improvement of spatial beam quality by use of the angular selectivity of a thick phase grating inserted into various laser cavities. Preliminary experiments with an intentionally degraded beam from a Nd:YVO4 laser have enhanced beam propagation factor M2 by a factor of 4.5. Operation with a broad-area laser diode in an external cavity with a thick grating was a...