tehran is one of the densely populated metropolises located in earthquake-prone regions. tehran, the population of which surpasses 8 million people, is the most populated area in iran. there are historical evidences confirming that catastrophic earthquakes have destroyed the city in past years. in the present paper, our study covers all parts of tehran because there is the potential of signific...

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement and pronounced racial and ethnic heterogeneity. The aims of the present work were (1) to describe the cumulative clinical characteristics of those patients included in the Spanish Rheumatology Society SLE Registry (RELESSER), focusing on the differences between patients who fulfilled the 1997...

OBJECTIVE To examine long-term organ damage and safety following treatment with belimumab plus standard of care (SoC) in patients with systemic lupus erythematosus (SLE). METHODS Pooled data were examined from two ongoing open-label studies that enrolled patients who completed BLISS-52 or BLISS-76. Patients received belimumab every four weeks plus SoC. SLICC Damage Index (SDI) values were ass...

Practicing physicians have requested efficacy and safety data for belimumab, when used with specific systemic lupus erythematosus (SLE) medications. This was a post hoc analysis of pooled efficacy and safety data from patients who received belimumab 10 mg/kg plus standard of care (SoC) or placebo (SoC) in two Phase III, randomized trials, BLISS-52 and BLISS-76. Patients were categorized into fo...

OBJECTIVES To relate the cognitive parameters of systemic lupus erythematosus (SLE) patients in remission to their profile of autoantibodies. MATERIAL AND METHODS The study included 32 patients with SLE in remission, with mild disease activity as indicated by SELENA-SLEDAI < 6. For neuropsychological assessment, the Cambridge Neuropsychological Test Automated Battery (CANTAB) was applied, usi...

Outcome assessments for flares in SLE trials have been both overly sensitive and non-specific, depending on the instrument being used. The article in this issue of Rheumatology by Thanou et al. [1], from a well-respected SLE centre, discusses proposed modifications to the classic Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA)-SLEDAI Flair Index (SFI). The SFI is defined ...

Title of Dissertation: SOCIAL POLICY AND SOCIAL SERVICES IN WOMEN’S PREGNANCY DECISIONMAKING: POLITICAL AND PROGRAMMATIC IMPLICATIONS Laura Selena Hussey, Doctor of Philosophy, 2006 Directed By: Professor James G. Gimpel, Department of Government and Politics This dissertation empirically evaluates the argument that welfare state expansion will reduce abortion. Its central question concerns the...

Background: Systemic lupus erythematosus (SLE) is a autoimmune disease that affects adolescents and young women of childbearing age. In spite the improvement in fetal maternal SLE pregnancy outcome last decades, they have increased risk adverse outcomes including flare, abortions, preeclampsia (PE) premature birth (PB). However, among with not been well explored. Objectives: To evaluate pregnan...

Background The efficacy of belimumab (BEL) for maintenance therapy in patients with systemic lupus erythematosus (SLE) remains unclear. Furthermore, the effects BLM on peripheral blood immunophenotype SLE are unknown. Objectives Patients phase were analyzed to determine relationship between BEL and immunophenotypes. This study aimed identify whom was optimal by clinical findings Methods In this...