Central diabetes insipidus (CDI) is characterized clinically by the presence of polyuria with the subsequent development of volume depletion and hypernatremia. In patients with dialysis-dependent end-stage renal disease (ESRD), neither of these findings can be expressed due to the absence of renal function. A 59-year-old woman with anuric ESRD of unknown etiology had been on peritoneal dialysis...

A 43-year-old male trisomic patient was referred for acute left headache and progressive homolateral mydriasis and ptosis. Computed tomography and T2-magnetic resonance imaging demonstrated a 4 cm invasive pituitary adenoma (Panels A and C, respectively). Blood analyses revealed hyperprolactinemia (5460 ng/ml, normal values < 15 ng/ml) and severe gonadotrophic insuffi ciency. Treatment was clas...