Abstract AIMS High grade gliomas are the most common CNS malignancies and cause ~200,000 deaths/year globally. Glioblastoma (WHO IV) confer worst prognoses with their treatment being hindered by glioma stem cell-like (GSC) tumour sub-regions high intratumoural spatio-heterogeneity. Tumour Treating Fields (TTFields) exert clinically approved alternating electric fields of intermediate frequency ...

Background Atopy varies in people of different ages owing to physical conditions and exposure allergens. We aimed cluster based on atopic severity using K-means analysis identify incidence, severity, as well the association among peripheral eosinophils, IgE sensitisation. Methods Consecutive patients (n = 7654) with allergic symptoms undergoing allergen-specific tests were included from 2013 20...

We read with interest the Review by Jo Nijs and colleagues1 describing central sensitisation in chronic pain conditions latest discoveries. agree authors that represents a significant unmet need. Here, we describe emerging nociceptive therapeutic potential of immunomodulatory strategies.

OBJECTIVES Organic acid anhydrides are potential sensitisers and cause occupational airway diseases. In an intervention study the efficacy of measures of hygiene at the workplace and possible selection bias were investigated. METHODS A first investigation with 110 workers exposed to hexahydrophthalic acid anhydride (HHPA) and methyltetrahydrophthalic acid anhydride (MTHPA) was carried out in ...

Objectives—Organic acid anhydrides are potential sensitisers and cause occupational airway diseases. In an intervention study the eYcacy of measures of hygiene at the workplace and possible selection bias were investigated. Methods—A first investigation with 110 workers exposed to hexahydrophthalic acid anhydride (HHPA) and methyltetrahydrophthalic acid anhydride (MTHPA) was carried out in July...