Septo-optic dysplasia (SOD)[MIM182230] consisting of a heterogeneous and uncommon condition characterised by the classictriad: optic nerve hypoplasia, abnormalities of pituitary hormone, and defects of thebrain midline (including agenesis of the septum pellucidum and/or the corpus callosum; ithas also been described associated cortical malformations, it was referred to as SOD plus syndrome).We ...

We reported previously the elicitation of presumably monosynaptic evoked field potentials in the dentate gyrus of immobilized rats by stimulation of the medial septal nuclei. The septo-hippocampal pathway mediating this evoked potential (SHEP) is widely assumed to be cholinergic in nature. In order to further verify this assumption we studied the effects of muscarinic drugs on the SHEPs. Scopol...

Thirty-one patients with optic nerve hypoplasia (ONH) or septo-optic dysplasia and two patients with segmental ONH underwent retinoscopy. The results were compared with those of 20 normal subjects. There was a higher prevalence of astigmatism in the patients than in the controls. Two patients with segmental ONH had no evidence of astigmatism. The association of astigmatism with ONH has not hith...

Septo-optic dysplasia (SOD) or Morsier syndrome is a rare congenital malformation of infantile neurodevelopment with systemic anatomical and functional involvement. It characterized by optic nerve hypoplasia, midline brain malformation, hypothalamic-pituitary axis hypoplasia. The spectrum clinical manifestations very wide, from ophthalmological problems to endocrinological disorders that determ...