The serotonin type IA (5-HT1A) receptors are members of a superfamily of seven transmembrane domain receptors that couple to GTP binding regulatory proteins (G-proteins). Serotonergic signalling has been shown to play an important role in alcohol tolerance and dependence. We have studied the effects of alcohols on ligand (agonist and antagonist) binding to bovine hippocampal 5-HT1A receptor in ...

Neurochemical imaging is one of the most established "molecular" imaging techniques. There have been tremendous efforts expended to develop radioligands specific to each neurochemical system. Investigational applications of neurochemical imaging in dementing disorders are extensive. Cholinergic, dopaminergic, and serotonergic systems, as well as benzodiazepine receptors, opioid receptors, and g...

Experiments were performed in vivo on chronically cannulated adult rainbow trout (Oncorhynchus mykiss) to assess the involvement of serotonergic or muscarinic receptor stimulation or activation of the renin-angiotensin system in eliciting catecholamine release during acute hypoxia during periods of nicotinic receptor desensitisation. Despite nicotinic receptor desensitisation induced by intrave...

To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. In the present report, we demonstrate that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces)....

Abbreviations: CRH: Corticotropin Releasing Hormone; CRH1: Corticotropin Releasing Hormone Receptor; CSF: Cerebro Spinal Fluid; D2: Dopaminergic Subreceptor; GABA: Gamma Amino Butyric Acid; GABAA: Gamma-Aminobutyric Acid Subtype A Receptors; GABAB: Gamma-Aminobutyric Acid Subtype B Receptors; Gal2: Galanin 2; 5-HT: Serotonergic Receptor; 5-HT1A: 5-Hydroxytryptamine 1A Receptors; 5-HT7: 5-hydrox...

Serotonin modulates behavioral plasticity in both vertebrates and invertebrates and in Caenorhabditis elegans regulates key behaviors, including locomotion, aversive learning and olfaction through at least four different 5-HT receptors. In the present study, we examined the serotonergic stimulation of aversive responses to dilute octanol in animals containing null alleles of these 5-HT receptor...

Chronic unpredictable stress (CUS) model of depression is one of the well validated animal models of depression. In this paper, we report the results of investigations into dopaminergic D-1 and serotonergic 5-HT-2A receptors in the brain of rats subjected to CUS procedure and treated chronically with imipramine. We have examined the dopaminergic D-1 ([3H-SCH 23390) in the limbic area and seroto...

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Several neurotransmission systems have been involved in function and dysfunctional memory (e.g., Myhrer, 2003; Decker and McGaugh, 2004; Reis et al., 2009; Cassel, 2010; Rodríguez et al., 2012; Komal andNashmi, 2015), including serotonin (5-hydroxytryptamine, 5-HT), which accounts with multiple neural markers (receptors, transporter; e.g., Hannon and Hoyer, 2008; Saulin et al., 2012; Seyedabadi...

In chronic smokers, nicotine withdrawal symptoms during tobacco cessation can lead to smoking relapse. rodent models, exposure elicited physical dependence, whereas acute antagonism of nicotinic acetylcholine receptors (nAChRs) immediately precipitated symptoms. Although the central serotonergic system plays an important role in withdrawal, exact raphe nuclei regulating these remain unknown. We...