An unusual protein AR was isolated from the amyloid fibril preparation derived from a patient with primary amyloidosis. Protein AR was unique in its antigenicity, and revealed no structural identity with any known amyloid proteins or with immunoglobulin chains or fragments. Thus a new third class of amyloid fibril proteins besides the immunoglobulin light-chain variable region fragments and the...

Objective- This study aims at validating the use of serum amyloid A (SAA) as biomarkers of surgical stress using Quantitative ELISA in the Sahel goats. The experiment evaluated SAA profiles of Sahel goats post Diazepam-Lidocaine (DLC) and Diazepam-Bupivacaine (DBC) local anaesthesia. Expressions of SAA in the Sahel goat post rumen skin clamp fixation techniques of rumenotomy wi...

Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the sera with antiserum to protein AA, the major constituent of casein-induced (...

BACKGROUND AND AIMS Growing interest in understanding the relationship between subjective memory complaints (SMCs) and objective measures of memory abilities emphasizes the importance of SMC assessment for diagnostic purposes. The present study investigated the relationship between SMCs and objective memory deficits in elderly adults by analysis of the factor structure of the Everyday Memory Qu...

Surface water systems such as rivers, lakes and ground water are affected by the natural processes such as erosion of minerals and dissolution of nutrients from the overlying rocks as well as anthropogenic influences from urban, industrial and agricultural activities. These degradation of surface water quality resulted in altered species composition and decreased overall health of aquatic commu...

A monoclonal antibody (YK-2), which was previously established to react with apolipoprotein E (apoE) peptides in systemic amyloid deposits, was further characterized. Epitope of this antibody was determined to be the residue 221 to 230 of apoE. In comparison with polyclonal anti-apoE antibodies, this antibody showed strong reactivity with apoE peptides in amyloid fibril preparation but poor rea...

Background To determine if 3-year changes in serum insulin resistance (IR) were related to brain volume and glucose uptake, cognition, CSF biomarkers cognitively unimpaired impaired older adults. Method Alzheimer’s Disease Neuroimaging Initiative data was downloaded for 275 aged adults (55-89 years). Participants had longitudinal T1- T2-weighted scans, fluorodeoxyglucose (FDG) β-amyloid (Aβ) ta...

Eight preparations of soluble amyloid and degraded amyloid (DAM) were compared immunologically. Unlike amyloid fibrils, six of eight preparations of DAM proved to be relatively strong immunogens. Antisera to DAM reacted weakly or not at all with normal human serum or extracts of normal tissues, but were specifically reactive with amyloid fibrils or DAM. Comparative studies of DAM'S from eight d...