We have examined the effect of the O-linked glycan (OLG) structures of VWF on its interaction with the platelet receptor glycoprotein Ibα. The 10 OLGs were mutated individually and as clusters (Clus) on either and both sides of the A1 domain: Clus1 (N-terminal side), Clus2 (C-terminal side), and double cluster (DC), in both full-length-VWF and in a VWF construct spanning D' to A3 domains. Mutat...

This communication reports the use of an electrohydrodynamic surface shear force to selectively manipulate colloid-surface interactions. We demonstrate the selection of strongly (specifically) bound biomolecule-functionalized colloidal beads over more weakly (non-specifically) bound beads using a tuneable alternating current electrohydrodynamic (ac-EHD) force, which drives lateral fluid motion ...

Chemical mechanical polishing (CMP) is a manufacturing process in which a wafer surface is polished by pressing it against a rotating pad that is flooded with slurry. The slurry itself is a fluid containing abrasive particles. Past experimentation has shown that the distribution of suspended particles in the slurry is significantly related to the distribution of material removal on the wafer du...

Virchow rightly recognised that blood flow plays an important role in thrombosis. The roles of blood flow in haemostasis, and in arterial, intra-cardiac, and venous thrombosis are reviewed. In streamline (laminar) flow, shear stresses are maximal at the vessel wall, and affect endothelial cell morphology and function (e.g. secretion of NO, prostacyclin,t-PA and vWF). Platelets are also concentr...

in reinforced concrete design, there are situations where transfer of shear across a specific plane needs to be considered. examples of such situation include corbels, bearing shoes, ledger beam bearing, and a host of connection between precast concrete elements. in this study, the shear transfer behavior of reinforced concrete is investigated experimentally by conducting test on 6 precracked p...

One of the most important factors in determining the depth of foundations in structures adjacent to the water flow is the scouring phenomenon; the scouring is a phenomenon caused by the interactions between water flow and erodible bed materials, which causes the removal of sediments where hydraulic structures are located, including bridge piers. Every year, a great number of bridges are damaged...

In many industrial processes, particle contamination is becoming a major issue. Particle detachment from surfaces can be detrimental, e.g. during lithographic processing. During cleaning however, detachment is aimed for. However, until recently, only little is known on the mechanism of particle detachment due to flowing gasses. In high throughput applications, large gas velocities are likely to...

Previous work has shown that organosilica-based xerogels have the potential to control biofouling. In this study, modifications of chemistry were investigated with respect to their resistance to marine slimes and to settlement of barnacle cyprids. Adhesion force measurements of bovine serum albumin (BSA)-coated atomic force microscopy (AFM) tips to xerogel surfaces prepared from aminopropylsily...

dual systems of steel moment frame and reinforced concrete shear wall have combined the advantages of steel frames and reinforced concrete shear wall. these walls have increased the lateral stiffness of steel frames and have reduced seismic demands on steel frames thus providing opportunities to use such system. in this research intermediate dual system of steel moment frame was chosen with int...