The esti mati on of the functions that descri be the shear stress and the pressure drop across the short orifice die as a function of shear rate at different mean pressures for linear-low-density polyethylene copolymer (LLDPE) at 190oC is obtained using Genetic Programmi ng (GP) . The GP has been running base d on e xpe rimental data in two cases; shear stress and pressure drop at differe nt me...

Bending analyses of isotropic, functionally graded, laminated composite, and sandwich beams are carried out using a quasi-3D polynomial shear and normal deformation theory. The most important feature of the proposed theory is that it considers the effects of transverse shear and transverse normal deformations. It accounts for parabolic variations in the strain/stress produced by transverse shea...

Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K(+) conductance, which suggests that ion channels are involved in the early shear stress response. Here we show that an applied shear stress ind...

Smooth muscle cells (SMCs) are organized in various patterns in blood vessels. Whereas straight blood vessels mainly contain circumferentially aligned SMCs, curved blood vessels are composed of axially aligned SMCs in regions with vortex blood flow. The vortex flow-dependent feature of SMC alignment suggests a role for nonuniform fluid shear stress in regulating the pattern formation of SMCs. H...

Pressure ulcer incidence rates have remained constant despite advances in support surface technology. Interface shear stress is recognized as a risk factor for pressure ulcer development and is the focus of many shear reduction technologies incorporated into wheelchair cushions; however, shear reduction has not been quantified in the literature. We evaluated 21 commercial wheelchair seat cushio...

Endothelial progenitor cells (EPCs) are mobilized from bone marrow to peripheral blood, and contribute to angiogenesis in tissue. In the process, EPCs are exposed to shear stress generated by blood flow and tissue fluid flow. Our previous study showed that shear stress induces differentiation of mature EPCs in adhesive phenotype into mature endothelial cells and, moreover, arterial endothelial ...

Podocytes are exposed to mechanical forces arising from glomerular capillary pressure and filtration. It has been shown that stretch affects podocyte biology in vitro and plays a significant role in the development of glomerulosclerosis in vivo. However, whether podocytes are sensitive to fluid shear stress is completely unknown. In the present study, we therefore exposed cells of a recently ge...

• Physiological shear stress promotes megakaryocytic maturation, DNA synthesis, phosphatidylserine exposure and caspase-3 activation. • Shear enhances the production and function of PLPs and Mk-derived microparticles possessing a novel function. In vivo visualization of thrombopoiesis suggests an important role for shear flow in platelet biogenesis. In vitro, shear stress was shown to accelerat...

Endothelial cells are the interface between hemodynamic fluid flow and vascular tissue contact. They actively translate physical and chemical stimuli into intracellular signaling cascades which in turn regulate cell function, and endothelial dysfunction leads to inflammation and diseased conditions. For example, atherosclerosis, a chronic vascular disease, favorably develops in regions of distu...

The laminar flow of a number of fluids such as polymeric liquids, food products, paints, slurries, foams, and so forth cannot be adequately described by the help of the classical linearly viscous Newtonian model. Thus, there is a need to have at hand an arsenal of non-Newtonian fluid models and over the past several decades a variety of models have been developed. While the fluids of the differ...