Hemodynamic shear stress from blood flow on the endothelium critically regulates vascular function in many physiological and pathological situations. Endothelial cells adapt to shear stress by remodeling their cytoskeletal components and subsequently by changing their shape and orientation. We demonstrate that β1 integrin activation is critically controlled during the mechanoresponse of endothe...

BACKGROUND AND PURPOSE Little attention has been focused on the role of fluid-induced wall shear stress in fully developed cerebral aneurysms. The purpose of this study is to evaluate the alternation and distribution of wall shear stress over 1 cardiac cycle in patients' aneurysms. METHODS A middle cerebral artery aneurysm and a basilar tip aneurysm with localized outpouching (blebs) in their...

This research aims to explore the dynamic characteristics and settlement prediction of soft soil. Accordingly, the dynamic shear modulus formula considering the vibration frequency was utilized and the dynamic triaxial test conducted to verify the validity of the formula. Subsequently, the formula was applied to the dynamic creep strain function, with the factors influencing the improved dynami...

Shear stress due to mechanical loading-induced flow of interstitial fluid through the lacuno-canalicular network is a likely signal for bone cell adaptive responses. Moreover, the rate (determined by frequency and magnitude) of mechanical loading determines the amount of bone formation. Whether the bone cells' response to fluid shear stress is rate dependent is unknown. Here we investigated whe...

Vascular endothelial cells (EC) are continuously exposed to shear stress associated with the flowing blood. Over the years, it has become clear that such shear exerts a multitude of effects on endothelial biology and vascular function and structure, ranging in time span from seconds to months. On the scale of seconds, shear-dependent vasodilation has been demonstrated in many experimental setti...

Compaction bands are localized, planar zones of compressed material that form perpendicular to the maximum compressive stress. Compaction bands have been observed in porous sandstone formations in the field and in laboratory compression tests on porous sandstone, plaster, glass beads, polycarbonate honeycombs and metal foams. Because the permeability of the compacted material is much reduced, c...

The three-dimensional tertiary structure of human von Willebrand Factor (vWF) on a hydrophobic surface under aqueous conditions and different shear stress regimes was studied by atomic force microscopy (AFM). vWF was imaged by AFM at molecular level resolution under negligible shear stress, under a local applied shear force (7.4 to 19 nN) using the AFM probe in contact mode scanning, and after ...

Frictional and frictionless granular materials in a split-bottom ring shear cell geometry show wide shear bands under slow, quasi-static deformation. Here, the differences between frictional and frictionless materials are elaborated using discrete element simulations (DEM). Several continuum fields like the density, the velocity field, the deformation gradient and the stress are used here for c...

In this paper, layerwise theory (LT) along with the first, second and third-order shear deformation theories (FSDT, SSDT and TSDT) are used to determine the stress distribution in a simply supported square sandwich plate subjected to a uniformly distributed load. Two functionally graded (FG) face sheets encapsulate an elastomeric core while two epoxy adhesive layers adhere the core to the face ...

Previous studies determined that shear stress imposed on bovine aortic endothelial cell (BAEC) monolayers increased the hydraulic conductivity (L(P)); however, the mechanism by which shear stress increases L(P) remains unknown. This study tested the hypothesis that shear stress regulates paracellular transport by altering the expression and phosphorylation state of the tight junction protein oc...