BACKGROUND Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) can provide insights into how differing cognitive contexts produce different brain states, through TMS-based measures of effective connectivity. For instance, in a recent study, the amplitude of the TMS-evoked response (TMS-ER) derived during the delay-period of a spatial short-term memory (STM) task ha...

Intracortical inhibition (ICI) and facilitation (ICF) of the human motor cortex can be induced by paired transcranial magnetic stimulation (TMS). Although demonstrated in experimental animals, the existence of intracortical inhibitory and excitatory circuits in parietal sensory cortex has not been documented in humans. The aim of this study was to investigate the effects of paired TMS of the pa...

Behavioral effects of transcranial magnetic stimulation (TMS) have been shown to depend on various factors, such as neural activation state, stimulation intensity, and timing of stimulation. Here we examined whether these factors interact, by applying TMS at either sub- or suprathreshold intensity (relative to phosphene threshold, PT) and at different time points during a state-dependent TMS pa...

OBJECTIVE There is growing interest in neuropsychiatry for repetitive transcranial magnetic stimulation (rTMS) as a neuromodulatory treatment. However, there are limitations in interpreting rTMS effects as a real consequence of physiological brain changes or as placebo-mediated unspecific effects, which may be particularly strong in psychiatric patients. This is due to the fact that existing sh...

TMS contaminates concurrent EEG recordings with Auditory Evoked Potentials (AEPs), which are caused by the perceived impulsive acoustic noise of coils. We hereby introduce a novel and perceptually motivated/tuned method for suppression auditory evoked artifacts rTMS under name “Auditory Fine-Tuned Suppressor TMS-Clicks” (TMS-click AFTS). The proposed is based on deployment psychophysically-matc...

OBJECTIVE The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) has been hampered by the large artifact that the TMS generates in the EEG. Using TMS with EEG necessitates a sophisticated artifact-resistant EEG system that can acquire reliable signals in the crucial several tens of milliseconds immediately following the TMS pulse. Here, we demonstrate the us...

Title: Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS Authors: Magdalena I Ivanova, Stuart A Sievers, Elizabeth L. Guenther, Lisa M. Johnson, Duane D. Winkler, Ahmad Galaleldeen, Michael R Sawaya, P. John Hart, David Eisenberg Corresponding author: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, De...

A bootstrap large deviation result for the mean is shown to be a consequence of a classical large deviation result due to Sievers and later improved by Plachky and Steinebach. The result implies a level of asymptotic correctness for nonparametric bootstrapping of the maximum likelihood estimator in models having a discrete parameter space. The application of bootstrap methods in molecular evolu...

Gerard Michel, Vanderson Rocha, Sylvie Chevret, William Arcese, Kah-Wah Chan, Alexandra Filipovich, Tsuneo A. Takahashi, Marcus Vowels, Juan Ortega, Pierre Bordigoni, Peter J. Shaw, Isaac Yaniv, Alexandra Machado, Pedro Pimentel, Franca Fagioli, Amparo Verdeguer, Jean Pierre Jouet, Blanca Diez, Euripedes Ferreira, Ricardo Pasquini, Joseph Rosenthal, Eric Sievers, Chiara Messina, Anna Paola Iori...