نتایج جستجو برای: sigma opioid receptor
تعداد نتایج: 634477 فیلتر نتایج به سال:
A. The endogenous opioid system and natural reinforcement 1383 B. The endogenous opioid system and drugs of abuse 1387 C. Perspectives: extending studies to animal models of drug addiction 1393 IV. Genetic Manipulation of the Opioid System, Reinforcement, and Drug Dependence 1393 A. Opioid receptor knockout mice 1393 B. Opioid peptide knockout mice 1394 C. Conclusion 1395 D. Perspectives: towar...
Opioid agonists have a broad range of effects on cells of the immune system, including modulation of the inflammatory response, and opioid and chemokine receptors are co-expressed by many white cells. Hetero-oligomerization of the human DOP opioid and chemokine CXCR2 receptors could be detected following their co-expression by each of co-immunoprecipitation, three different resonance energy tra...
Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse. Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin. Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Mu opioid receptor gene variants: lack of association with alcohol d...
conclusions the study results demonstrated that preemptive use of dextromethorphan reduced postoperative pain and opioid consumption. patients and methods this double blind randomized clinical trial was conducted on arthroscopic surgery candidates. participants were randomly allocated to interventions and assigned to two groups of dextromethorphan and placebo. in dextromethorphan group, the pat...
Introduction: Oxytocin is a active neuropeptide of central nervous system. In this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (LC) nucleus were investigated. Methods: Adult male Wistar rats were used. Animals divided into different groups receiving saline, oxy...
Opioid abuse is a growing global problem. Current therapies for opioid target withdrawal symptoms and have several adverse side effects. There are no treatments to address opioid-induced neural adaptations associated with addiction. Preclinical research demonstrates interactions between the endogenous cannabinoid systems, suggesting that cannabinoids may be used treat addiction dependence. The ...
Morphine injected locally to the paw of an adult or an infant rat is analgesic. Opiates specific to micro and kappa opioid receptors, and less consistently to delta opioid receptors, given locally to the site of injury in adult animals are also analgesic in a variety of models of inflammatory pain. To determine which opioid receptor(s) are involved in local analgesia in the immature animal, ago...
Objective: In this study, it was aimed to investigate the antinociceptive activity potential of Tofisopam and elucidate possible involvement opioid system in effect.Material Method: The efficacy (25 50 mg/kg) evaluated by hot-plate acetic acid-induced writhing tests; while effects drug on motor coordination mice were with Rota-rod tests.Result Discussion: at a dose mg/kg significantly prolonged...
Two highly selective mu-opioid receptor agonists, endomorphin-1 and endomorphin-2, have been identified and postulated to be endogenous mu-opioid receptor ligands. We determined the antinociceptive effects of these two ligands at the supraspinal level in mice with the tail-flick and hot-plate responses. The i.c.v. injection of endomorphin-1 and -2 inhibited the tail-flick and hot-plate response...
Background µ-Opioid receptor internalization is considered to be critically linked to antinociceptive tolerance. Although µ-opioid receptor agonists have been administered simultaneously with other drugs to control pain, little information is available regarding opioid–opioid interactions. Therefore, the present study was designed to further investigate the utility of a new G protein-biased lig...
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