Background:Oncoba spinosa, an endangered medicinal plant whose secondary metabolites have not been extensively profiled, and which is hitherto yet to be examined for cytotoxicity, is being investigated in this study. Methods: Leaves of Oncoba spinosa (800 g) were extracted with 95% aqueous methanol. The crude extract was partitioned with n-hexane and the resultant defatted extract was extensive...

During the purification of macrosphelides A and B in the cultured broth of FO-5050, we discovered two new 1 6-memberedmacrocyclic compounds, macrosphelides C (1) and D (2) (Fig. 1). This paper describes physicochemical properties structural determination and biological activities of 1 and 2. The fermentation of strain FO-5050 was carried out in the same way as reported previously1}. Compound 1 ...

Resolution of racemic tert-butyl-1-(2-methylnaphthyl)-phosphine oxide 1, a chiral phosphorus compound, was achieved using selectors developed from a small peptide library. Separation factors as high as 3.2 were observed. The library consists of 81 peptide-based potential chiral selectors on polymeric synthesis resins. The linker needed to immobilize the identified chiral selectors onto silica g...

PTFE-based coatings have been widely used, for example, on aluminium moulds for moulding of polyolefin packaging materials for its non-stick property. However, these coatings do not meet the users’ scratch resistance and durability requirements. This paper describes a preliminary study on the synthesis and characterization of a PTFE/sol-gel composite coating material which combines the required...

The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of controlled adsorption and desorption. The poorly water soluble drug compound itraconazole and the...

A molecular detection method utilizing the magnetically induced aggregation of silver nanoparticle (NP)-embedded silica NPs for SERS activation is described. Here, silver embedded magnetic NPs (Ag-M-dots) composed of a magnetic core and silica shells, on whose surface silver NPs were formed, were used. Because the magnetic field induced aggregated Ag-M-dots exhibit a strong SERS signal compared...

background: satureja mutica (lamiaceae) is an herbaceous plant which grows in north-west of iran. oleanolic acid has been previously isolated from some lamiaceae genus and showed a broad range of biological activities. besides silphium spp., panax quinquefolium root and calendula officinalis flower as the interesting source of oleanolic acid used in the herbal industry, here we report the isola...

In a screening programme for search of antibiotics active against clinical resistant strains of infectious bacteria, a potent antibiotic producer from soil capable of acting on vancomycin and methicillin resistant strains was isolated. The taxonomic and biochemical studies revealed that the culture was a strain of Streptomyces californicus. The fermentation schedule was determined in starch cas...

UNLABELLED The leaves of Ritchiea capparoides var. longipedicellata (Capparidaceae) is used in ethnomedicine in South-Western Nigeria to treat infectious and parasitic diseases. This study was aimed at identifying the compound(s) that are responsible for the antimicrobial and antiplasmodial activities of the leaves and also to contribute to the chemistry of the plant species. A 70 % aqueous eth...