INTRODUCTION Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor physical therapy are unsuccessful, intradetrusor injection of botulinum toxin-A ...

A single injection of 10(5) U/kg of recombinant rat IFN-gamma increases the amount of tissue dendritic cells up to sixfold, and concomitantly induces the (capillary) endothelial cells to express class II MHC antigens. Both responses peak on the third day after IFN-gamma injection, and the antigen expression returns to basic levels on day 7. Simultaneous administration of 1 mg/kg/d of methylpred...

A simultaneous flow-injection analysis (FIA) manifold that could analyse three ions from a single injection was designed, constructed, calibrated and used successfully to analyse Li(+), Na(+) and K(+). This FIA method was 10 times faster than the batch technique. The sample volume required was a fraction of about 1/110 to 1/75 that of the batch technique. The outputs were quite reproducible and...

The blood of 63 human subjects selected because of the absence of recent infections, was studied for its content of specific antibodies against virulent strains of Types I, II, and III pneumococci before and after intracutaneous injections of minute amounts of pneumococcus products. The simultaneous injection of the specific polysaccharides of all three types of pneumococci and of proteins and ...

To investigate the safety profile and benefits of a short-term simultaneous treatment regimen combining two drugs-an intravitreal implant of dexamethasone with an intravitreal injection of bevacizumab-in patients with macular edema. This was a retrospective, non-randomized, open-label case series study. Patients were treated between April 2014 and July 2015 and were diagnosed with recurrent mac...

We report a theoretical study to determine the temperature profiles due continuous andconstant injection of hot water through line source, into homogeneous fluid-saturated porous medium which has had initially constant T∞. In our treatment we have taken in account simultaneous fluxes volume fluid, q, and heat, φ. By using far-field description, found similarity solutions for dimensionless depending ...

The possible interaction between cholinergic and dopaminergic influences in the induction of yawning behavior in the rat is explored resorting to several experimental approaches: comparison of the ontogeny of yawning behavior induced by physostigmine (0.15 mg/kg) and apomorphine (0.05 mg/kg); simultaneous injection of both drugs; "crossed blocking" experiments, in which the action of the cholin...

This paper addresses the application of optimization transfer to simultaneous statistical estimation of attenuation and activity images in tomographic image reconstruction. Although the technique we propose has wider applicability, we focus on the problem of reconstructing from data acquired via a post-injection transmission scan protocol. In this protocol, emission scan data is supplemented wi...

PURPOSE The aim of this study was to assess the treatment failures of island-flap anoplasty for fistula-in-ano, a procedure designed to treat fistula without sphincter division. METHODS Data concerning all patients having dermal island-flap anoplasty for the treatment of transsphincteric fistula were reviewed. Variables assessed were age, gender, radial fistula location, cause, Crohn's diseas...

Growth of a murine fibrosarcoma was suppressed when tumor cells were mixed with viable Listeria monocytogenes (LM) before intradermal injection into nonimmune syngeneic recepients. Immunization of recipients, by intravenous injection of LM 11 days before transplantation of LM-tumor cell mixtures, eliminated the mortality associated with large doses of LM but did not alter the antitumor activity...