Children are known to be particularly vulnerable to the effects of noise on speech perception, and it is commonly acknowledged that failure of central auditory processes can lead to these difficulties with speech-in-noise (SIN) perception. However, little is known about the mechanistic relationship between central processes and the perception of SIN. Our aims were twofold: to examine the effect...

To determine the role of nitric oxide (NO) in rat liver transporter regulation, we investigated in precision-cut liver slices the effect of NO and peroxynitrite (ONOO(-)), a reaction product of NO with superoxide (O(2(-))), on mRNA levels of 13 influx and efflux transporters. To inactivate Kupffer cells (KCs), liver slices were prepared from rats treated with gadolinium chloride (Gd). Transport...

When nutrients are abundant, S. pombe cells grow as rods, dividing by fission after formation of a medially placed cell wall or division septum. Septum formation is triggered by a group of proteins, called the septation initiation network or SIN, that trigger contraction of the acto-myosin contractile ring at the end of mitosis. Ectopic activation of the SIN can uncouple septum formation from o...

3a An instructive toy model: two paradoxes We start with a very simple random trigonometric polynomial (even simpler than 1c12): (3a1) X(t) = ζ cos t+ η sin t where ζ, η are independent N(0, 1) random variables. Its distribution is the image of γ under the map (x, y) 7→ (t 7→ x cos t+ y sin t). Time shifts of the trigonometric polynomial correspond to rotations of R, (3a2) X(t− α) = ζ(cos t cos...

Recently it has been demonstrated that large phases in softly broken supersymmetric theories are allowed by electric dipole moment constraints, and are motivated in some string models. Here we consider whether large soft phases in the supersymmetry breaking sector may be the dominant (or only) source of all CP violation, and demonstrate that ǫ and ǫ/ǫ can be described. We show that in the prese...

The snail Helix nemoralis in negatively geotropic creeping orients upward upon an inclined surface until the angle of the path of progression (theta) is related to the tilt of the surface (alpha) as (Delta sin theta) (Delta sin alpha) = - const.; theta is very nearly a rectilinear function of log sin alpha. The precision of orientation (P.E.(theta)) declines in proportion to increasing sin alph...

The septation initiation network (SIN) and mitotic exit network (MEN) signaling pathways regulate cytokinesis and mitotic exit in the yeasts Schizosaccharomyces pombe, and Saccharomyces cerevisiae, respectively. One function of these pathways is to keep the Cdc14-family phosphatase, called Clp1 in S. pombe, from being sequestered and inhibited in the nucleolus. In S. pombe, the SIN and Clp1 act...

The channel fluorine implantation (CFI) process was integrated with the Si₃N₄ contact etch stop layer (SiN CESL) uniaxial-strained n-channel metal-oxide-semiconductor field-effect transistor (nMOSFET) with the hafnium oxide/silicon oxynitride (HfO₂/SiON) gate stack. The SiN CESL process clearly improves basic electrical performance, due to induced uniaxial tensile strain within the channel. How...

Las Vegas, Nevada sells sex without much discussion of the potential negative consequences to this overtly sexual environment. This paper will look at rates of sexual assault in this self-described adult playground. Criminal justice professionals in Las Vegas acknowledge struggling with elevated rates of sexual victimization. Assault rates were considered through multiple sources of data. Feder...