aChange in Hamilton Depression Rating Scale (HDRS) (A) and Beck Depression Inventory (BDI) (B) mixed-model analysis results are noted on figures, with *P < .05 and **P < .01 on a last-observationcarried-forward paired t test (gray bar represents remission cut-off). The relationship between acute improvement after ketamine (day 1) vs improvement after 8 weeks of d-cycloserine treatment (C) is sh...

In a double-blind trial the response to treatment with Ferro-Gradume (a slow-release preparation of ferrous sulphate) has been compared in the same individuals with the response to ferrous fumarate in a single daily dose regimen using a similar dose of iron. No significant difference was found in the therapeutic response or in the incidence of side-effects between the two preparations.

In the normal subject the level of circulating cortisol is regulated by a feed-back mechanism so that an increase in plasma cortisol results in diminished secretion of corticotrophin by the pituitary. Synthetic corticosteroids act on the feed-back mechanism in a similar manner to endogenous cortisol, and a single dose will inhibit corticotrophin release and hence cortisol production. The degree...

Objective(s): Reproductive dysfunction is a consequence of diabetes. Diabetes is associated with changes in testicular tissue. Sesame oil contains large amounts of polyunsaturated fatty acids and lignin with antioxidant activity, vitamin E, and monounsaturated fatty acid (MUFA). The present study investigated the effects of sesame on testis histology and male reproductive parameters in streptoz...

AIM To compare stress resistance increasing and analgesic activities of piperlongumine and a methanolic Piper longum fruit extract (PLE). METHODS Efficacies of a single and repeated daily oral doses (1-256 mg/kg/day) of PLE, piperlongumine, and 50 mg/kg/day doxycycline against foot shock stress triggered alteration in body weights and core temperatures, and of their 11 daily doses on antidepr...

to investigate and compare the infectious and non-infectious complications of single-dose versus multiple-dose antibiotic therapy for trans-rectal ultrasound (trus)-guided biopsy of the prostate. patients were enrolled in a prospective randomized study that was designed to investigate the effects of single-dose versus multiple-dose antimicrobial prophylaxis regimen mainly on asymptomatic bacter...

AIMS To compare the effect on intraocular pressure (IOP) of latanoprost applied once daily with four times daily and to study if the difference persisted when treatment changed to once daily. METHODS IOP was followed in 28 healthy volunteers in a double masked randomised 52 day study. Latanoprost 50 microg/ml was administered once daily in one eye and four times daily in the other during 2 we...

The thrombopoietic efficacy of recombinant forms of c-mpl ligand is being actively investigated in preclinical studies using daily dosing schedules. However, a comprehensive kinetic study of the thrombopoietic response to a single injection of recombinant c-mpl ligand has not been performed. Here, we present the results of a detailed kinetic analysis of the platelet response to a single intrave...

BACKGROUND Tenapanor, a small molecule with minimal systemic availability, is a first-in-class sodium/hydrogen exchanger 3 (NHE3) inhibitor that acts in the gut. Here, we evaluate the pharmacodynamics and safety of tenapanor in healthy adults. METHODS Two phase I, single-center, randomized, double-blind, placebo-controlled studies were performed. The first study assessed single-ascending oral...