The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and...

Joints and interfaces are one of the key aspects design production composite structures. This paper investigates effect adhesive–adherend interface morphology on mechanical behavior wavy-lap joints with aim to improve performance. Intentional deviation from a flat joint plane was introduced in different bond angles (0°, 60°, 90° 120°) were subjected quasi-static tensile load. Comparisons made r...

This paper presents a finite element numerical method to assess the stress state and gradients induced by thermo-oxidative ageing in Ti/epoxy/Ti adhesively bonded joints for aircraft engine applications. The is dealing with couplings between thermal, chemistry mechanics occurring during high-temperature of joint, taking into account post-curing stresses, under mechanical loading. Calculations a...

Lapatinib (LAP), an oral tyrosine kinase inhibitor for the treatment of metastatic breast cancer, has been associated with idiosyncractic hepatotoxicity. Recent investigations have implicated the importance of P450 3A4/5 enzymes in the formation of an electrophilic quinone imine (LAPQI) metabolite generated through further oxidation of O-dealkylated lapatinib (OD-LAP). In the current study, hep...

The microstructural properties of a Pb-free solder joint significantly affect its mechanical behaviours. This paper details systematic study the effect annealing process on microstructure and shear strength Zn-added Sn-0.7Cu joint. results indicated that IMC layer’s thickness at solder/Cu interface increases with time. interfacial layer gradually thickened increasing time temperature, while mor...