Published reports and personal experience are reviewed relating to patients under 1 year of age diagnosed with a vein of Galen malformation and congenital heart disease. Including five patients from this institution, a total of 23 patients (12 neonates) with congenital heart disease and a vein of Galen malformation have been reported. Six of these had sinus venosus atrial septal defect and nine...

Transvenous pacemaker and/or defibrillator lead placement into the left heart chambers is rarely done. Approximately a third of such cases reported in the literature presented with signs of thromboembolism, mostly neurological deficits. We describe a patient who presented with a cerebrovascular accident three months after inadvertent and unrecognized lead placement into the left atrium and vent...

TOPIC: Cardiovascular Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: Sinus venosus atrial septal defects (SVASD) is an uncommon ASD variant occurring in 5-10% of cases. Unrepaired can cause left to right shunt and heart volume overload which progress pulmonary hypertension. Patients become symptomatic between the third fifth decades life. CASE PRESENTATION: A 46-year-old male...

We read the article published by Laguna et al with interest. However, in the wake of that reading, we would like to make a few comments that we believe to be important. The sinus venosus forms part of the right atrium during embryonic development. Over the course of this period, the left cusp of the sinus venosus valve is incorporated into the septum secundum, whereas the right cusp gives rise ...

BACKGROUND We present a study of the heart malformations found in a collection of mouse fetuses of the iv/iv strain between days 16.5 and 18.5 of gestation. METHODS AND RESULTS One hundred hearts were serially sectioned and studied by segmental analysis with a light microscope. Forty additional hearts were analyzed with a scanning microscope. Forty percent of the hearts were found to be malfo...

The effects of sympathetic nerve stimulation on beat rate, force, intracellular Ca2+ concentration ([Ca2+]i) measured using fura 2, and membrane potential were recorded from the spontaneously beating toad sinus venosus. Short trains of stimuli evoked an increase in the beat rate and force. During this tachycardia the amplitude of pacemaker action potentials was not changed, but there was an inc...