Despite the many clinical and pathological data which have accumulated about the heredo-familial ataxias, Gardner's comment on Friedreich's disease almost 50 years ago, that ". . . the chief point to bear in mind about its aetiology is the tendency it shows to run in families" (Gardner, 1906), remains true of the group today. In consequence, the knowledge to be derived from the investigation of...

PURPOSE To study, by a new, integrated, laser scanning confocal microscopy approach, the ocular surface morpho-functional unit in patients with primary Sjogren syndrome (SSI), non-Sjogren syndrome dry eye (non-SSDE), and meibomian gland disease (MGD). METHODS Patients and age- and sex-matched control subjects (N = 60; 15 each) were consecutively enrolled in a prospective case-control study. L...

Renal tubular acidosis (RTA) may develop in a large population of patients with Sjogren's syndrome (SS), but most of the subjects are asymptomatic. Here, we report a patient with known rheumatoid arthritis and symptoms of xerostomia, xerophthalmia and periodic paralysis. SS should be considered as a cause of RTA. The treatment of the underlying disorder may ameliorate the symptoms.

MSS. intended for publication and books, etc., intended for review should be sent to The Editor of Science, Garrison-onHudson, N. Y. THE ORGANIZATION OF THIE MEDICAL PROFESSION FOR WAR' I FEEL greatly honored by the election to the position of president of the American Alediea.l Association. I recognize inot only tile honor but also the responsibility of assuming the leadership of the organized...

PURPOSE A medical school's mission statement (MS) is an expression of its vision and a reflection of the broader social environment in which it is embedded. The authors examine how the institutional identity of U.S. medical education is projected through the MSs of all U.S. MD-granting medical schools. In addition, the authors examine the extent to which differences between subsets of schools (...