A significant proportion of heart failure patients develop skeletal muscle wasting and cardiac cachexia, which is associated with a very poor prognosis. Recently, myostatin, a cytokine from the transforming growth factor-β (TGF-β) family and a known strong inhibitor of skeletal muscle growth, has been identified as a direct mediator of skeletal muscle atrophy in mice with heart failure. Myostat...

Background. Exertional fatigue, which frequently limits exercise in patients with chronic heart failure, is associated with early anaerobic metabolism in skeletal muscle. The present study was designed to examine the skeletal muscle metabolic response to exercise in this disorder and determine the relation of reduced muscle blood flow and skeletal muscle biochemistry and histology to the early ...

Increased skeletal muscle capillarization is associated with improved glucose tolerance and insulin sensitivity. However, a possible causal relationship has not previously been identified. Therefore, we investigated whether increased skeletal muscle capillarization increases insulin sensitivity. Skeletal muscle-specific angiogenesis was induced by adding the α1-adrenergic receptor antagonist pr...

the objective of this study was to evaluate the effect of dietary supplements with lead acetate and aluminosilicates (atn) on antioxidative enzyme activities and lipid peroxidation of the heart and skeletal muscle tissues of broiler chickens. broilers were allotted to four diets including the control group, the pb group, the aluminosilicate-atn (antitoxic nutrient) group and the pb+atn group, i...

Metabolic abnormalities develop in various chronic diseases and lead to progressive catabolism with decrements in the skeletal musculature that result in muscle atrophy. We investigated pathways of skeletal muscle proteolysis using an experimental model of chronic left-ventricular dysfunction. Skeletal muscle atrophy developed in wild-type mice 12 weeks following myocardial infarction accompani...

Background. Due to the lack of sufficient information about the interactive effects of high intensity intermittent training (HIIT) and blood flow restricted (BFR) exercises on angiogenic variables of skeletal muscle, it seems that integration these training models can influence skeletal muscle angiogenesis in the long term over the individual application of each of these training methods. Obje...

Repetitive stimulation potentiates contractile tension of fast-twitch skeletal muscle. We examined the role of myosin regulatory light chain (RLC) phosphorylation in this physiological response by ablating Ca(2+)/calmodulin-dependent skeletal muscle myosin light chain kinase (MLCK) gene expression. Western blot and quantitative-PCR showed that MLCK is expressed predominantly in fast-twitch skel...

BACKGROUND To compare the relationship of skeletal muscle mass with bone mineral content in an ethnically diverse group of 6 to 18 year old boys and girls. METHODS 175 healthy children (103 boys; 72 girls) had assessments of body mass, height, and Tanner stage. Whole body bone mineral content, non-bone lean body mass (nbLBM), skeletal muscle mass, and fat mass were assessed using dual-energy ...

McGrath, Meagan J., Christina A. Mitchell, Imogen D. Coghill, Paul A. Robinson, and Susan Brown. Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces 5 1-integrin-dependent myocyte elongation. Am J Physiol Cell Physiol 285: C1513–C1526, 2003. First published August 13, 2003; 10.1152/ajpcell.00207.2003.—Skeletal muscle LIM protein 1 (SLIM1/FHL1) contains four and a half LIM domains and is highly e...