A membrane-coated fiber (MCF) array approach was developed for quantitative assessment of skin absorption from chemical mixtures, which was based on the similarity in the absorption mechanisms of the MCF membrane and the stratum corneum of the skin. A set of probe compounds were used to detect the relative molecular interaction strengths of chemicals with the vehicle and the membranes, which pr...

The question of the potential for exposure to inorganic arsenic in water through dermal contact is important when providing guidance about treatment options to private well owners. If dermal contact with the water is an exposure route of concern, then whole house treatment is required, while if only oral exposure is considered, then treatment at the kitchen tap will be sufficient. For this reas...

Salicylic acid was applied topically to the skin of rabbits and humans in order to study the pharmacokinetics of percutaneous absorption, and the effects of formulation and application variables on the rate and extent of absorption. Drug samples incorporated into hydrophilic ointment (USP} and hydrophilic ointment containing 10% urea, were applied to the shaved abdominal areas of female New Zea...

Nd:YAP laser emitting at 1342 nm appears promissing for nonablative skin rejuvenation, due to lower absorption in epidermal melanin and higher absorption in water as compared to the 1064 nm light from Nd:YAG lasers. The aim of our study was to verify these relations in vivo and quantify the energy deposition depth of a Nd:YAP laser in intact human skin. A comparison with the results obtained wi...

An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a Pluronic lecithin organogel and Pentravan Cream. Each formulation was applied to ex vivo human trunk skin (from three skin donors) on triplicate sections mounted onto Franz Diffusion Cells. Following a 5-mcL/cm2 applied dose, serial dermal receptor so...

purpose: to describe a patient with eyelid sarcoidosis. case report: a 54 year-old patient was referred for an eyelid mass from 6 months ago.excisional biopsy showed inflammatory granuloma with tuton gaint cells. chest radiograph demonstrated bilateral hilar adenopathy, increased absorption on gallium scan was noted and bronchoalveolar lavage confirmed a diagnosis of sarcoidosis. treatment with...

There is growing emphasis in the United States and Europe regarding the quantification of dermal exposures to chemical mixtures and other substances. In this paper, we determine the dermal flux of benzene in neat form, in organic solvents, and in aqueous solutions based on a critical review and analysis of the published literature, and discuss appropriate applications for using benzene dermal a...

Neat N-methyl-2-pyrrolidone (NMP) rapidly penetrated into the skin of male Sprague-Dawley rats after in vivo and in vitro topical application. At the two topical doses tested in vivo, no steady state was observed. The maximal absorption fluxes were 10 and 20 mg/cm/h for 20 l/cm and 40 l/cm, respectively. Similar results were observed after in vitro topical application of neat [C]NMP (25–400 l/c...

Skin conditions are common in all age ranges, and can significantly affect an individual's quality of life. Nurses prescribing or applying topical treatments should have a comprehensive understanding of skin barrier function and the effects this has on the absorption of medication through the skin. This article focuses on the therapeutic options available to treat skin conditions with particula...