Optical interrogation of suspicious skin lesions is standard care in the management of skin cancer worldwide. Morphological and functional markers of malignancy are often combined to improve expert human diagnostic power. We propose the evaluation of the combination of two independent optical biomarkers of skin tumours concurrently. The morphological modality of reflectance confocal microscopy ...

Keratinocyte skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common cancer occurring in people with fair skin, worldwide. Despite all known triggers, several suggested contributors are still investigated. We will focus our attention on the personal history of previous cancers and radiation exposure as occupational risk factors, as in the presen...

T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive post-thymic malignancy that is characterized by the proliferation of small- to medium- sized prolymphocytes. The classic clinical features of T-PLL are lymphocytosis, lymphadenopathy, hepatosplenomegaly, and skin lesions. Skin involvement varies clinically from diffuse infiltrated erythema. Infiltration is localized to the face and...

Cutaneous pseudolymphomas (CPLs) include a wide range of clinicopathological presentations sharing in common the presence of clinical and histopathological features mimicking those of primary cutaneous lymphomas. Although immunophenotypical studies and molecular analysis of clonality have been shown to be reliable tools, providing significant help in the differential diagnosis between primary c...

Pilomatricoma is benign skin adnexal tumour arising from the hair follicle matrix. Its most common location is maxillofacial region followed by upper extremities. Lower extremities are a rare site for this tumour. It presents as a skin nodule and rarely exceeds 5 cm in diameter. We are thus presenting an unusual case of pilomatricoma on thigh of a young male which was clinically thought to be a...

Neurofibromatosis type 1 (NF1) is a genetic disorder commonly associated with an increased risk for development of malignancy, including skin cancers. Herein we describe a case of invasive melanoma occurring in a patient with NF1 and discuss the association between these two diseases, highlighting the importance of comparative clinical and dermoscopic approaches in this category of patients in ...

liposarcoma is a mesenchymal malignant tumor and is the second-most common soft tissue sarcoma in adults. primary peritoneal liposarcoma is very rare. we report a case of abdominal liposarcoma originating from peritoneum in 57-year old woman, presenting with hugeness of abdomen.   the symptoms had been begun from one month ago without any pain, discomfort or gastrointestinal symptoms. in physic...

background : skin cancer is the most common malignancy in the world. thus, the aim of this study was to determine the incidence trend of skin cancer in isfahan province, iran. methods: the present cross-sectional study was conducted using data registered during 2004-2008 in the disease management center and cancer registry system of the ministry of health and medical education. the trend of ski...

Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...