background necrosis of skin flaps is considered as an important complication in reconstructive surgery. we conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. methods forty male, adult sprague-dawlay rats were divided randomly into 4 groups. standard rectangular, distally based dorsal random...

BACKGROUND Ganglion is one of the common lesions seen in minor surgical practice. Treatment of dorsal wrist ganglia varies from simple reassurance to excision and advanced endoscopic excision. Irrespective of the treatment modality, recurrence is a common problem. MATERIALS AND METHODS This study evaluates results of 40 wrist ganglia treated by using the transfixation technique. RESULTS Out...

Inadvertent leakage of medications with vesicant properties can cause severe necrosis in tissue, which can have devastating long-term consequences. The aim of this study was to evaluate the extent of extravasation injury induced by thiopental and propofol, and the effects of cooling or warming of local tissue on extravasation injury at macroscopic and histopathologic levels. Rats were administe...

Pain is the most conspicuous symptom observed in patients wounded by stingrays, and skin necrosis is common in accidents by freshwater stingrays. The extract from the stinger integumentary tissue of Potamotrygon falkneri containing toxic components (venom) was tested for its ability to induce histopathological changes in the dorsal skin of mice at different times. 3-6 h after injection, foci of...

BACKGROUND Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. METHODS Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal ran...

BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal random-pattern ski...

Pressure necrosis of the skin is a rarely reported avoidable complication of prone positioning that can be minimised by active collaboration between care teams. We report a case of pressure necrosis of the chin after prone ventilation in the intensive care setting. Such injuries pose a risk of infection, possible need for surgical intervention, and increased costs to the health care system. Pre...

Neurovaccinia virus propagated in the presence of bromodeoxyuridine loses the capacity to produce necrosis in the skin of rabbits. Mechanisms underlying this loss were studied. The population under study consisted predominantly of virus particles capable of producing necrosis (RS +) and a small portion of particles which had lost this capacity (RS-). An RSclone isolated from the population indu...

Background: Paederus dermatitis, an acute erythemato-vesiculo-bullous dermatitis contracted through contact with the secretions of the Paederus species, is frequently seen among the people living in the south-west part of our country during spring and early summer months. Objective: This study was conducted to elucidate the responsible arthropod in Khuzestan province and to study the clinical s...