BACKGROUND Mycobacterium tuberculosis lipid antigens take part in pathogenicity of the bacterium but the response of monocytes/macrophages to these antigens in tuberculosis is not well known. OBJECTIVE The aim of current investigation was to study the M. tuberculosis lipid antigens in tuberculosis pathogenesis. METHODS In the present study M. tuberculosis lipid antigens were extracted. Mono...

BACKGROUND In patients with intrathoracic lymphadenopathy, differentiating tuberculosis from sarcoidosis is often difficult. We hypothesized that Xpert MTB/RIF assay, a semi-automated hemi-nested PCR would help in this regard. OBJECTIVE To evaluate the performance of Xpert MTB/RIF in the differential diagnosis of tuberculosis and sarcoidosis. METHODS This was a retrospective analysis of pat...

A 52-year-old men was referred with a 6-months history of a 3cm single skin lesion, erythematous, not pruriginous, with a verrucous surface, surmounted by scales, with circinated border. His history included weight loss of 8kg, but no other associated symptoms or contact with tuberculosis patients. Erythrocyte sedimentation rate (ESR) was slightly elevated at 82mm in the first hour. Mycological...

DISSEMINATED MYCOBACTERIUM TUBERCULOSIS WITH ULCERONECROTIC CUTANEOUS DISEASE PRESENTING AS CELLULITIS Abstract Cutaneous tuberculosis is a rare manifestation of infectious tuberculosis caused by invasion of the skin by Mycobacterium tuberculosis. Tuberculous cellulitis is a rare type of cutaneous tuberculosis with cellulitis-like symptoms. Only eight cases of tuberculous cellulitis have been r...

The association of leprosy and cutaneous tuberculosis has been reported rarely. Though cross-immunity may exist between these two mycobacterial infections, tuberculosis can occur throughout the spectrum of leprosy. We report a case of lepromatous leprosy with Type II reaction, with tuberculosis verrucosa cutis (TVC). The patient presented with multiple skin-coloured tender nodules of variable s...

The adverse reactions of anti-tuberculosis drugs mainly include drug-induced liver injury, gastrointestinal reactions, and skin rash. Currently, the first-line anti-tuberculosis strategy in China includes the application of isoniazide, rifampicin, pyrazinamide, and ethambutol. Despite the high effectiveness, the serious adverse reactions caused by this strategy may cause a lot of patients disco...

Primary inoculation tuberculosis results from the direct inoculation of Mycobacterium tuberculosis into the skin of a person who has no natural or artificially acquired immunity to the organism. The pathogenesis requires a break in the skin from an abrasion or injury that allows entry of the tubercle bacilli. We report 3 cases of primary inoculation tuberculosis resulting from illegal acupunctu...