BACKGROUND AND AIMS Neuropilin 1 (NRP1) is a non-tyrosine kinase receptor for vascular endothelial growth factor (VEGF) and class 3 semaphorins, playing a role in angiogenesis and neuronal axon guidance, respectively. NRP1 is expressed in smooth muscle cells (SMC) but the functional role of NRP1 in SMC has not been elucidated. We therefore investigated the biological relevance of NRP1 in SMC in...

The relationship between degradation of basement membranes, metalloproteinase (MMP) activity and smooth muscle cell (SMC) migration and proliferation has not been previously investigated in any intervention study. We used adenoviral overexpression of tissue inhibitors of metalloproteinases (TIMPs) in cultured human saphenous veins. By immunocytochemistry, the percentage of medial SMC surrounded...

To test the hypothesis that chronic intrauterine pulmonary hypertension (PHTN) compromises pulmonary artery (PA) smooth muscle cell (SMC) O2 sensing, fluorescence microscopy was used to study the effect of an acute increase in Po2 on the cytosolic Ca2+ concentration ([Ca2+]i) of chronically hypoxic subconfluent monolayers of PA SMC in primary culture. PA SMCs were derived from fetal lambs with ...

Abstract We present mosaic images of the Small Magellanic Cloud (SMC) observed with Spitzer IRAC 3.6 μ m and 4.5 bands over two epochs, 2017 August 25–2017 September 13 November 24–2018 February 12. The survey region comprises ∼30 deg 2 covering SMC Bridge to Large Cloud. is covered by 52 ∼ 1.°1 × tiles, each tile including in band for both separate combined epochs. mosaics are made individual ...

This article proposes a cascade proportional-integral second-order sliding mode control (PI-SMC) method for matrix converter-fed brushless doubly fed induction machine (BDFIM). The PI-SMC consists of PI speed controller with an inner-loop (SMC). provides reference to the SMC constraints according system requirements in terms maximum current and speed. As discontinuous sign function traditional ...

There is much interest in defining the signals that initiate abnormal proliferation of cells in a variety of states characterized by the presence of mononuclear phagocytes. Since IL-1 is a major secretory product of activated human monocytes we examined whether this cytokine can stimulate the growth of human vascular smooth muscle cells (SMC). Neither recombinant IL-1 (rIL-1) alpha (less than o...

OBJECTIVE The goal of the present study was to identify novel mechanisms that regulate smooth muscle cell (SMC) differentiation marker gene expression. APPROACH AND RESULTS We demonstrate that the CArG-containing regions of many SMC-specific promoters are imbedded within CpG islands. A previously identified GC repressor element in the SM myosin heavy chain (MHC) promoter was highly methylated...

Self-modifying codes (SMC) refer to programs that intentionally modify themselves at runtime, causing the runtime code to differ from the static binary representation of the code before execution. Hence SMC is an effective method to obstruct software disassembling. This paper presents a method which circumvents the SMC protection, thus improving the performance of disassembling. By disabling th...