The steady expansion in the capacity of modern beamlines for high-throughput data collection, enabled by increasing X-ray brightness, capacity of robotics and detector speeds, has pushed the bottleneck upstream towards sample preparation. Even in ligand-binding studies using crystal soaking, the experiment best able to exploit beamline capacity, a primary limitation is the need for gentle and n...

The objective of this study was to understand the factors that affect the hydration and cooking profiles of different bean varieties. During this study, nine bean varieties were classified as either easy-to-cook (ETC) or hard-to-cook (HTC) based on a subjective finger pressing test and an objective cutting test. Rose coco, Red haricot, and Zebra beans were classified as ETC, while Canadian wond...

Practice can dramatically reduce dual-task interference, but typically does not eliminate interference entirely. Residual interference after practice is especially large with certain non-preferred modality pairings (e.g., auditory-manual and visual-vocal). Does this residual interference imply the existence of a persistent central-processing bottleneck? To address this question, we transferred ...

In this research, the controversial issue of whether the central bottleneck can be bypassed through task automatization was investigated. To examine this issue, participants received six single-task practice sessions with an auditory-vocal task (low vs. high pitch). We then assessed dual-task performance using the analytically tractable psychological refractory period (PRP) paradigm, in which t...

The authors examined the role of online order control in the psychological refractory period (PRP) paradigm. In the first 2 experiments, participants switched between color-letter and letter-color orders so that subtask order was isolated as the only element being switched. The results indicated that order switching impaired the 2 PRP responses and modulated the PRP effect. Importantly, these e...

The divergent predictions of 2 models of dual-task performance are investigated. The central bottleneck and central capacity sharing models argue that a central stage of information processing is capacity limited, whereas stages before and after are capacity free. The models disagree about the nature of this central capacity limitation. The central bottleneck model claims that central processin...

Some studies suggest that dual-task processing impairs sequence learning; others suggest it does not. The reason for this discrepancy remains obscure. It may have to do with the dual-task procedure often used. Many dual-task sequence learning studies pair the serial reaction time (SRT) task with a tone-counting secondary task. The tone-counting task, however, is not ideal for studying the cogni...

In this paper we give various equivalent characterizations of upper estimates of heat kernels of regular, conservative and local Dirichlet forms on doubling spaces, from both the analytic and probabilistic points of view. The first part of this paper uses purely analytic arguemtn, while the second part focuses on the probabilistic aspects where the exit time plays an important role.