Chronic aldosterone (Aldo) excess is associated with transient sodium retention, extracellular fluid volume expansion, renal vasodilation, and hypertension. The purpose of this study was to determine the role of nitric oxide (NO) in mediating the renal vasodilation and the escape from the sodium-retaining actions of Aldo. To achieve this goal, we examined the long-term effects of Aldo (15 μg ⋅ ...

The objective of this study is to determine the antimutagenic effect honey and its correlation with concentration total polyphenolic content. Seven samples were collected from different regions Algeria. content was determined by Folin-Ciocalteu colorimetric assay. carried out AMES Salmonella/ microsome mutagenicity assay against three known mutagenic substances (4-nitro-o-phenylenediamine, sodi...

The reaction of P-diketones 1 with phenyl hydrazine afforded 5-aryl-3-(1- methyl-5-nitro-2-imidazoly1)-1-phenylpyrazole (2) and 3-aryl-5-(1-methyl-5- nitro-2-imidazoly1) -1-phenylpyrazole (3). The reaction of diketones (1) with urea in the presence of p-toluenesulfonic acid gave 4-(or 6-)aryl-6-(or 4-)(1-methyl- 5-nitro-2-imidazolyl)-1-(lH)pyrimidones (4). The structures of all compounds w...

The title compound, 1-carbamoylguanidinium bis-(2,4,6-tri-nitro-phen-yl)amide [H2NC(=O)NHC(NH2)2](+)[N{C6H2(NO2)3-2,4,6}2](-) (= guanylurea dipicryl-amide), was prepared as dark-red block-like crystals in 70% yield by salt-metathesis reaction between guanylurea sulfate and sodium dipicryl-amide. In the solid state, the new compound builds up an array of mutually linked guanylurea cations and di...

Copper (II) phthalocyanine and 2,9,16,23 tetrakis nitro copper (II) phthalocyaninehas been synthesized respectively from phthalonitrile and 4-nitro phthalonitrile under solvent-free condition using two different catalystsovernanodimensionalzeolites. 4-Nitro phthalonitrile synthesized from phthalimide in three steps. The newly prepared compounds have been characterized by IR, UV-Vis, 1</sup...

endothelial cell (HUVEC) and bovine aertic endothelial cell surface proteoglycans was significantly decreased by the incubation with SNAP andNOR4, poterrt nitric oxide (NO) donors. NO derived from lipopolysaccharide-stiinulated J774 A-1 cells also decreased the binding of EC-SOD to HUVEC, and this decrease was blocked by NG-nitro-L-arginine, a itric oxide synthase inhibiter. Furthermore. the de...

Submit Manuscript | http://medcraveonline.com Abbreviations: HR: Hypersensitive Response; SAR: Systemic Acquired Resistance; WIPK: Wound-Induced Protein Kinase; SIPK: Salicylic Acid-Induced Protein Kinase; TCA: Trichloroacetic Acid; 2-ME: 2-Mercaptoethanol; SDS: Sodium Dodecyl Sulphate; PMSF: Phenyl Methyl Sulfonyl Fluoride; 2DE: 2D Gel Electrophoresis; DTT: Dithiothreitol; aact: Acetyl-CoA C-A...

A mild, convenient and transition metal free methodology for oxidative ipso nitration of diversely functionalized organoboronic acids, including heteroaryl- and alkylboronic acids, has been developed at ambient temperature using a combination of [bis-(trifluoroacetoxy)]iodobenzene (PIFA) - N-bromosuccinimide (NBS) and sodium nitrite as the nitro source. It is anticipated that the reaction proce...