PolarClean, a green solvent prepared through the valorization of byproduct Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents additives. It can also swell polystyrene ChemMatrix, two resins most widely used in solid-phase peptide synthesis. The synthesis model peptides has been carried out, rendering target as major component. performa...

A rapid and simple method for separation of serum lipid classes for fatty acid analysis with a single aminopropyl solid phase glass column is described. The recoveries of cholesteryl esters, triglycerides, free fatty acids, and phospholipids were all at least 98%. Coefficients of variation less than 10% were obtained for absolute and relative amounts of most individual fatty acids analyzed afte...

This chapter describes the basic protocols for solid-phase peptide synthesis using the Fmoc group as the N (α)-protecting group (Fmoc-SPPS). The chapter introduces resins and their handling, choice of linkers, and the most common methods for peptide chain assembly. The proper choice of resins and linkers for solid-phase synthesis is a key parameter for successful peptide synthesis. This chapter...

The N-acylation of ethanolamine (2) with various fatty acids 1a-d and esters of fatty acids 1e-h using Candida antarctica B lipase (Novozym((R)) 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy ...

Dr. Ghosh has presented a novel technique for the con­ version of Municipal Waste (MSW) to methane rich gas. Prior work has either permitted fermentation to proceed naturally (landfill gas extraction) or used conventional stirred reactors (DOE Ref COM facility). Proposed is to recycle leachate through a mass of solid waste to achieve volatile acids and then to convert the acids to methane in a ...

Continuous flow chemical processes offer several advantages as compared to batch chemistries. These are particularly relevant in the case of heterogeneously catalyzed transformations of biomass-derived platform molecules into valuable chemicals and fuels. This work is aimed to provide an overview of key continuous flow processes developed to date dealing with a series of transformations of plat...

A solid-phase radioiodination technique for wiodophenyl fatty acids using ammonium sulfate is described. The radioiodinations are (I) regioselective, (2) high in yield (95%), (3) short in reaction time (I h) and (4) capable of yielding high specific activity products although at lower yields. Purification is exceptionally simple: a single passage through an ion exchange column to remove unreact...