The aim of the present study was to develop and characterise polymeric composite pellets by means of continuous melt extrusion techniques. Powder blends of a steroid hormone (SH) as a model drug and either ethyl cellulose (EC N10 and EC P7 grades) or hydroxypropyl methylcellulose (HPMC AS grade) as polymeric carrier were extruded using a Pharma 11mm twin screw extruder in a continuous mode of o...

We developed o-triazenylarylboronic acids as stable solid aryne precursors, which generate arynes under mild conditions using silica gel the sole reagent and undergo reactions with a range of arynophiles both in solution solid-state.

Purpose Paediatric solid cancers such as osteosarcoma, Ewing ́s sarcoma, rhabdomyosarcoma and neuroblastoma are the most common cancers in children besides leukemia. These cancers have a poor prognosis, are highly metastatic and often resistant to current therapeutic approaches. Viscum album L. (mistletoe) is one of the most widely used complementary cancer therapies in Germany but little is kno...

The identification of low abundance target nucleic acids in a complex matrix can be challenging due to the abundance background material. Current methods use two-step processes which are time consuming, prone to contamination and usually limited to one pathogen. In this study we describe a single-step target-capture approach using magnetic microbeads with capture probes covalently attached thro...

Tightening environmental legislation is driving the fine and speciality chemicals industries to consider alternative processes that avoid the use of conventional mineral acids. The use of heterogeneous catalysts in these processes would vastly simplify catalyst removal, minimizing the amount of waste formed. However, diffusion limitation of liquids within porous solids dictates that effective s...

Abstract. Gibbs energies of formation of CoF2 and MnF 2 have been measured in the temperature range from 700 to l t00 K using Al203-dispersed CaF 2 solid electrolyte and Ni + NiF2 as the reference electrode. The dispersed solid electrolyte has higher conductivity than pure CaF2 thus permitting accurate measurements at lower temperatures. However, to prevent reaction between A120 3 in the solid ...