Solubility is an important physicochemical factor affecting absorption of drug and there by its therapeutic effect. About 40% of newly discovered drugs are lipophilic and failed to reach market due to their poor water solubility. Solid dispersions proved to have tremendous potential for improving drug solubility. Orlistat is a poor water soluble substance possessing anti-obesity property; in th...

INTRODUCTION The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. METHODS Solid dispersion formulations with different carriers including crospovidone, microcrystalline cellulose, Elaeagnus angustifolia fruit powder, with different drug to carrier ratios were prepared employing cogrinding method. Dissolution st...

This paper describes the enhancement of dissolution rate of nifluminic acid by spray dry process, as a solid dispersion method using polyvinylpyrrolidone (PVP C-15) as a water soluble polymer. Using solid dispersions as a well-known principle on an industrial scale, it has to be combined with low-cost and repetable manufacturing method. Therefore, the aim of the authors was the amorphisation of...

The poor solubility and wettability of meloxicam leads to poor dissolution and hence showing variations in bioavailability. The present study is aimed to increase solubility and dissolution of the drug using solid dispersion techniques. The solid binary systems were prepared at various drug concentrations (5-40%) with polyethylene glycol 6000 by different techniques (physical mixing, solvent ev...

The concept of a relaxation spectrum is used to compute the absorption and dispersion of a linear anelastic solid. The Boltzmann aftereffect equation is solved for a solid having a linear relationship between stress and strain and their first time derivatives, the 'standard linear solid', and having a distribution of relaxation times. The distribution function is chosen to give a nearly constan...

The canonical problem of the diffraction of a transient elastic plane wave by a semiinfinite fluid-filled crack in an unbounded, homogeneous, isotropic, dispersive solid is considered. The dispersion properties of the solid (and its associated loss mechanism) are accounted for by general, global relaxation functions that meet the causality criterion and encompass the influence of frictional for...

A quantum theory of dispersion for an inhomogeneous solid is obtained, from a starting point of multipolar coupled atoms interacting with an electromagnetic field. The dispersion relations obtained are equivalent to the standard classical Sellmeir equations obtained from the Drude-Lorentz model. In the homogeneous ~planewave! case, we obtain the detailed quantum mode structure of the coupled po...

In this paper, we investigated the corrected plasmon dispersion relation for graphene in presence of a constant magnetic field which it includes a quantum term arising from the collective electron density wave interference effects. By using quantum hydrodynamic plasma model which incorporates the important quantum statistical pressure and electron diffraction force, the longitudinal plasmons ar...

Poorly solubility in water of many newly developed high-potential drugs is an obstacle in formulation development. The aim of this study was to increase the solubility of Lamotrigine which is a poorly soluble drug and comes under BCS class-II by using solid dispersion technique. Lamotrigine, PEG 4000 and PVPK-30 solid dispersion was prepared by solvent evaporation method and the formulation was...

The aim of the present study was to improve solubility and dissolution of the poorly aqueous soluble drug, etoricoxib by solvent evaporation technique using various sugar carriers, such as lactose, sucrose, and mannitol. Etoricoxib solid dispersions and their respective physical mixtures using lactose, sucrose, and mannitol were prepared in different ratios by solvent evaporation technique. The...