Invasive aspergillosis (IA) occurs in 1–15% of the solid organ transplant (SOT) recipients. Mortality rate in transplant recipients with IA historically has ranged from 65% to 92% (1–4). However, currently reported mortality rate in IA among SOT recipients is 22% (5). An estimated 9.3– 16.9% of all deaths in transplant recipients in the first year have been considered attributable to IA (6). Al...

INTRODUCTION Bilateral carotid artery dissection following blunt trauma is a rare but potentially lethal injury if not diagnosed early and treated. CASE REPORT We report a collision patient who suffered bilateral asymptomatic carotid artery dissections. He also had multiple fractures of the pelvis and upper and lower extremities. The patient was managed acutely with aspirin. He underwent open...

A frequent problem in transplantation is allograft survival, which can be exacerbated by nonimmune mechanisms in response to perioperative injury of the blood vessels.1 In addition to inflammatory responses, nonimmune mechanisms may also contribute to the development of graft arteriosclerosis (GA), found frequently in cardiac allografts.2 GA of the coronary arteries, or cardiac allograft vascul...

Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood supply returns to tissue after a period of ischemia and is associated with trauma, stroke, myocardial infarction, and solid organ transplantation. Although the cause of this injury is multifactorial, increasing experimental evidence suggests an important role for the innate immune system in initiating the infl...

RATIONALE Resistant cytomegalovirus-mediated infections are increasing in solid organ recipient with few available alternative treatments. Brincidofovir is an oral broad-spectrum antiviral in development for prevention and treatment of viral infection, particularly cytomegalovirus. PATIENTS CONCERNS Although brincidofovir is an analogue of cidofovir, previous studies reported no renal toxicit...

Since the discovery of nitric oxide (NO) in biological systems more than 20 years ago, it became widely accepted that endogenous NO plays a key role in the regulation of a variety of physiological processes. NO is involved in reperfusion injury and chronic rejection after solid organ transplantation. Arginase is an enzyme that competes with NO synthases for the common substrate L-arginine. Incr...

BACKGROUND The epidemiology and outcomes of acute kidney injury (AKI) in prevalent non-renal solid organ transplant recipients is unknown. METHODS We assessed the epidemiology of trends in acute kidney injury (AKI) in orthotopic cardiac and liver transplant recipients in the United States. We used the Nationwide Inpatient Sample to evaluate the yearly incidence trends (2002 to 2013) of the pr...

hydrocarbons are ubiquitous in daily life and include plant and animal fats, alcohols, solvents, natural gas, petroleum derivates. majority of intoxication reports of hydrocarbons are due to inhalation or ingestion, but there is few reports about intravenous injection of gasoline. we report a 58 year-old man who injected gasoline intravenously for suicide. he developed soft tissue necrosis of f...